Biometric Technology, Inc.

Bis(phenylethynyl)arene Linkers in Tetracationic bis-Triarylborane Chromophores Management Fluorimetric and Raman Sensing of Numerous DNA and RNA

 

We report Four new luminescent tetracationic bis-triarylborane DNA and RNA sensors that present excessive binding affinities, in a number of instances even within the nM vary. Three of the compounds comprise substituted, extremely emissive, and structurally versatile bis(2,6-dimethylphenyl-4-ethynyl)arene linkers (3: arene=5,5′-2,2′-bithiophene; 4: arene=1,4-benzene; 5: arene=9,10-anthracene) between the 2 boryl moieties and function environment friendly twin Raman and fluorescence chromophores.

The shorter analogue 6 employs bis(2,6-dimethylphenyl)-9,10-anthracene because the linker and demonstrates the significance of an satisfactory linker size with a sure degree of flexibility by exhibiting typically decrease binding affinities than 3-5. Pronounced aggregation-deaggregation processes are noticed in fluorimetric titration experiments with DNA for compounds Three and 5. Molecular modelling of complexes of 5 with AT-DNA, counsel the minor groove because the dominant binding web site for monomeric 5, however exhibit that dimers of 5 can be accommodated. Sturdy SERS responses for 3-5 vs. a really weak response for six, notably the robust indicators from anthracene itself noticed for five however not for six, exhibit the significance of triple bonds for robust Raman exercise in molecules of this compound class.

The vitality of the attribute stretching vibration of the C≡C bonds is considerably depending on the fragrant moiety between the triple bonds. The insertion of fragrant moieties between two C≡C bonds thus presents another design for twin Raman and fluorescence chromophores, relevant in multiplex organic Raman imaging

DNA / RNA Damage Antibody
abx440602-100ug	Abbexa	100 ug	EUR 551

DNA / RNA Damage Antibody
abx440883-100ug	Abbexa	100 ug	EUR 551

DNA / RNA Damage Antibody
abx441164-100ug	Abbexa	100 ug	EUR 551

DNA / RNA Damage Antibody
abx441445-100ug	Abbexa	100 ug	EUR 551

DNA / RNA Damage Antibody
abx441726-100ug	Abbexa	100 ug	EUR 551

DNA / RNA Damage Antibody
abx442007-100ug	Abbexa	100 ug	EUR 551

DNA / RNA Damage Antibody
abx442288-100ug	Abbexa	100 ug	EUR 551

DNA / RNA Damage Antibody
abx442569-100ug	Abbexa	100 ug	EUR 551

DNA / RNA Damage Antibody
abx442850-100ug	Abbexa	100 ug	EUR 551

DNA / RNA Damage Antibody
abx443130-100ug	Abbexa	100 ug	EUR 551

DNA / RNA Damage Antibody
abx443410-100ug	Abbexa	100 ug	EUR 537

DNA / RNA Damage Antibody
abx443691-100ug	Abbexa	100 ug	EUR 565

DNA / RNA Damage Antibody
abx443972-100ug	Abbexa	100 ug	EUR 551

DNA / RNA Damage Antibody
abx444253-100ug	Abbexa	100 ug	EUR 551

DNA / RNA Damage Antibody
abx444534-100ug	Abbexa	100 ug	EUR 551

DNA / RNA Damage Antibody
20-abx444884	Abbexa	EUR 495.00 EUR 328.00	100 ug 25 ug

Monoclonal antibody for DNA/RNA Damage
SMC-155C	Stressmarq	0.025mg	EUR 190
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

Monoclonal antibody for DNA/RNA Damage
SMC-155D	Stressmarq	0.1mg	EUR 332
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A390	Stressmarq	0.1mg	EUR 379
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 390.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A488	Stressmarq	0.1mg	EUR 378
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 488.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A565	Stressmarq	0.1mg	EUR 378
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 565.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A594	Stressmarq	0.1mg	EUR 378
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 594.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A633	Stressmarq	0.1mg	EUR 378
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 633.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A655	Stressmarq	0.1mg	EUR 378
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 655.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A680	Stressmarq	0.1mg	EUR 378
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 680.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A700	Stressmarq	0.1mg	EUR 378
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 700.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-ALP	Stressmarq	0.1mg	EUR 372
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Alkaline Phosphatase.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-APC	Stressmarq	0.1mg	EUR 377
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-APCCY7	Stressmarq	0.1mg	EUR 450
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC/Cy7.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-BI	Stressmarq	0.1mg	EUR 374
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Biotin.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY350	Stressmarq	0.1mg	EUR 393
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 350.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY405	Stressmarq	0.1mg	EUR 381
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 405.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY488	Stressmarq	0.1mg	EUR 371
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 488.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY594	Stressmarq	0.1mg	EUR 373
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 594.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY633	Stressmarq	0.1mg	EUR 368
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 633.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-FITC	Stressmarq	0.1mg	EUR 370
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with FITC.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-HRP	Stressmarq	0.1mg	EUR 366
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with HRP.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-P594	Stressmarq	0.1mg	EUR 385
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PE/ATTO 594.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-PCP	Stressmarq	0.1mg	EUR 377
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PerCP.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-RPE	Stressmarq	0.1mg	EUR 375
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with RPE.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-STR	Stressmarq	0.1mg	EUR 376
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Streptavidin.

Monoclonal antibody for DNA/RNA Damage
SMC-155S	Stressmarq	0.012mg	EUR 65
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

DNA Damage Quantification Kit
55R-1345	Fitzgerald	25 assays	EUR 844
Description: Assay Kit for Quantification of DNA Damage in the research laboratory

DiscoveryProbe? DNA Damage/DNA Repair Library
L1033-.1	ApexBio	100 uL/well(10 mM solution)	EUR 3889

DiscoveryProbe? DNA Damage/DNA Repair Library
L1033-.25	ApexBio	250 uL/well(10 mM solution)	EUR 6905

DiscoveryProbe? DNA Damage/DNA Repair Library
L1033-5	ApexBio	5 mg/well	EUR 9005

OxiSelect Nitrosative DNA/RNA Damage ELISA Kit (8-Nitroguanine Quantitation)
STA-825	Cell Biolabs	96 assays	EUR 798
Description: The OxiSelect Nitrosative DNA/RNA Damage ELISA Kit is a competitive enzyme immunoassay developed for rapid detection and quantitation of 8-nitroguanine in urine, serum, or plasma samples.

OxiSelect Nitrosative DNA/RNA Damage ELISA Kit (8-Nitroguanine Quantitation)
STA-825-5	Cell Biolabs	5 x 96 assays	EUR 3240
Description: The OxiSelect Nitrosative DNA/RNA Damage ELISA Kit is a competitive enzyme immunoassay developed for rapid detection and quantitation of 8-nitroguanine in urine, serum, or plasma samples.

Navy RNA Lysis Kit 50
NAVYE1-RNA	Next Advance	50pack	EUR 198
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Navy RNA Lysis Kit 250
NAVYE5-RNA	Next Advance	250pack	EUR 651
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Green RNA Lysis Kit 50
GREENE1-RNA	Next Advance	50pack	EUR 180
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Green RNA Lysis Kit 250
GREENE5-RNA	Next Advance	250pack	EUR 571
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Pink RNA Lysis Kit 50
PINKE1-RNA	Next Advance	50pack	EUR 178
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Pink RNA Lysis Kit 250
PINKE5-RNA	Next Advance	250pack	EUR 561
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RNA Lysis Kit 50
YELLOWE1-RNA	Next Advance	50pack	EUR 192
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RNA Lysis Kit 250
YELLOWE5-RNA	Next Advance	250pack	EUR 624
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RNA Lysis Kit 50
REDE1-RNA	Next Advance	50pack	EUR 192
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RNA Lysis Kit 250
REDE5-RNA	Next Advance	250pack	EUR 622
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

5E Navy RNA Lysis Kit 100
NAVY5E100-RNA	Next Advance	100pack	EUR 453
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

5E Navy RNA Lysis Kit 20
NAVY5E20-RNA	Next Advance	20pack	EUR 153
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Navy RINO RNA Lysis Kit 50
NAVYR1-RNA	Next Advance	50pack	EUR 202
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free.

Navy RINO RNA Lysis Kit 250
NAVYR5-RNA	Next Advance	250pack	EUR 666
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free.

5E GREEN RNA Lysis Kit 100
GREEN5E100-RNA	Next Advance	100pack	EUR 386
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 1000, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

5E GREEN RNA Lysis Kit 20
GREEN5E20-RNA	Next Advance	20pack	EUR 138
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Green RINO RNA Lysis Kit 50
GREENR1-RNA	Next Advance	50pack	EUR 184
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free.

Green RINO RNA Lysis Kit 250
GREENR5-RNA	Next Advance	250pack	EUR 587
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free.

5E PINK RNA Lysis Kit 100
PINK5E100-RNA	Next Advance	100pack	EUR 380
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

5E PINK RNA Lysis Kit 20
PINK5E20-RNA	Next Advance	20pack	EUR 136
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Pink RINO RNA Lysis Kit 50
PINKR1-RNA	Next Advance	50pack	EUR 181
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Pink RINO RNA Lysis Kit 250
PINKR5-RNA	Next Advance	250pack	EUR 576
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RINO RNA Lysis Kit 50
YELLOWR1-RNA	Next Advance	50pack	EUR 199
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RINO RNA Lysis Kit 250
YELLOWR5-RNA	Next Advance	250pack	EUR 656
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

5E RED RNA Lysis Kit 100
RED5E100-RNA	Next Advance	100pack	EUR 429
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

5E RED RNA Lysis Kit 20
RED5E20-RNA	Next Advance	20pack	EUR 148
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RINO RNA Lysis Kit 50
REDR1-RNA	Next Advance	50pack	EUR 195
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Red RINO RNA Lysis Kit 250
REDR5-RNA	Next Advance	250pack	EUR 638
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

DNA Damage Quantification Colorimetric Kit
K2100-25	ApexBio	25 assays	EUR 627

DNA Damage Quantification Colorimetric Kit
K253-25	Biovision		EUR 610

VAHTS DNA Damage Repair Kit
N208-01	Vazyme	24 rxn	EUR 263

VAHTS DNA Damage Repair Kit
N208-02	Vazyme	96 rxn	EUR 642

100 BP DNA LADDER, 500UL PER KIT
M-DNA-100BP	CORNING	1/pk	EUR 73
Description: Bioscience Mol Bio; DNA Ladder

1 KB DNA LADDER, 500UL PER KIT
M-DNA-1KB	CORNING	1/pk	EUR 70
Description: Bioscience Mol Bio; DNA Ladder

DiscoveryProbe? DNA Damage/DNA Repair-related Compounds Panel
L1007-5	ApexBio	5 mg/well	EUR 5977
Description: A wide range of well-characterized bioactive molecules that covers various targets related to DNA damage/DNA repair, including ATM/ATR, HDAC, and topoisomerase etc. Facilitate your research towards the insights of cancer, genome instability and immune diseases etc.

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx125748	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx125750	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx129884	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
20-abx123209	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx112119	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
20-abx112120	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

DNA Damage Induced Apoptosis Suppressor (DDIAS) Antibody
20-abx323435	Abbexa	EUR 314.00 EUR 244.00	100 ug 50 ug

DNA Damage-Binding Protein 2 (DDB2) Antibody
20-abx338922	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx004988	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx103576	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx000607	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx026524-400ul	Abbexa	400 ul	EUR 523

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx026524-80l	Abbexa	80 µl	EUR 286

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx027183-400ul	Abbexa	400 ul	EUR 523

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx027183-80l	Abbexa	80 µl	EUR 286

 

DNA/RNA Fluorescence Imaging by Artificial Nucleic Acids

 

Fluorescence imaging of nucleic acids is a key expertise wanted to know gene expression and the ensuing adjustments in mobile operate. This chapter focuses on sequence-specific fluorescence imaging of nucleic acids in cells utilizing fluorescent nucleic acids. The design and preparation of fluorescent nucleic acids and their utility to fluorescence imaging of intracellular nucleic acids are launched.

Staphylococcus aureus membrane vesicles comprise immunostimulatory DNA, RNA and peptidoglycan that activate innate immune receptors and induce autophagy

 

Gram-positive micro organism ubiquitously produce membrane vesicles (MVs), and though they contribute to organic capabilities, our data concerning their composition and immunogenicity stays restricted. Right here we study the morphology, contents and immunostimulatory capabilities of MVs produced by three Staphylococcus aureus strains; a methicillin resistant scientific isolate, a methicillin delicate scientific isolate and a laboratory-adapted pressure. We noticed variations in the quantity and morphology of MVs produced by every pressure and confirmed that they comprise microbe-associated molecular patterns (MAMPs) together with protein, nucleic acids and peptidoglycan. Evaluation of MV-derived RNA indicated the presence of small RNA (sRNA). Moreover, we detected variability within the quantity and composition of protein, nucleic acid and peptidoglycan cargo carried by MVs from every S. aureus pressure. S. aureus MVs activated Toll-like receptor (TLR) 2, 7, 8, 9 and nucleotide-binding oligomerization area containing protein 2 (NOD2) signalling and promoted cytokine and chemokine launch by epithelial cells, thus figuring out that MV-associated MAMPs together with DNA, RNA and peptidoglycan are detected by sample recognition receptors (PRRs).

Furthermore, S. aureus MVs induced the formation of and colocalized with autophagosomes in epithelial cells, whereas inhibition of lysosomal acidification utilizing bafilomycin A1 resulted in accumulation of autophagosomal puncta that colocalized with MVs, revealing the power of the host to degrade MVs by way of autophagy. This research reveals the power of DNA, RNA and peptidoglycan related to MVs to activate PRRs in host epithelial cells, and their intracellular degradation by way of autophagy. These findings advance our understanding of the immunostimulatory roles of Gram-positive bacterial MVs in mediating pathogenesis, and their intracellular destiny inside the host.

Yeasts as a promising supply platform for DNA and RNA vaccines

 

Yeasts are thought of a helpful system for the event of vaccines for human and veterinary well being. Species reminiscent of Saccharomyces cerevisiae and Pichia pastoris have been used efficiently as host organisms for the manufacturing of subunit vaccines. These organisms have been additionally explored as vaccine autos enabling the supply of antigens reminiscent of proteins and nucleic acids. The employed species possess a GRAS standing (Typically Acknowledged as Protected) for the manufacturing of therapeutic proteins, in addition to selling immunostimulation as a result of properties of their wall cell composition.

This technique permits the administration of nucleic acids orally and a selected supply to skilled antigen-presenting cells (APCs). On this assessment, we search to stipulate the event of entire yeast vaccines (WYV) carrying nucleic acids in several approaches within the medical area, in addition to the immunological features of this vaccine technique. The info offered right here reveal the appliance of this platform in selling efficient immune responses within the context of prophylactic and therapeutic approaches.

Nonadiabatic Absorption Spectra and Ultrafast Dynamics of DNA and RNA Photoexcited Nucleobases

 

We have now not too long ago proposed a protocol for Quantum Dynamics (QD) calculations, which relies on a parameterisation of Linear Vibronic Coupling (LVC) Hamiltonians with Time Dependent (TD) Density Purposeful Principle (TD-DFT), and exploits the most recent developments in multiconfigurational TD-Hartree strategies for an efficient wave packet propagation. On this contribution we discover the potentialities of this method to compute nonadiabatic vibronic spectra and ultrafast dynamics, by making use of it to the 5 nucleobases current in DNA and RNA. For all of them we computed the absorption spectra and the dynamics of ultrafast inner conversion (100 fs timescale), totally coupling the primary 2-Three shiny states and all of the shut by darkish states, for a complete of 6-9 states, and together with all the traditional coordinates.

We adopted two completely different functionals, CAM-B3LYP and PBE0, and examined the impact of the idea set. Computed spectra are in good settlement with the obtainable experimental information, remarkably bettering over pure digital computations, but additionally with respect to vibronic spectra obtained neglecting inter-state couplings. Our QD simulations point out an efficient inhabitants switch from the bottom vitality shiny excited states to the close-lying darkish excited states for uracil, thymine and adenine. Dynamics from higher-energy states present an ultrafast depopulation towards the extra steady ones. The proposed protocol is sufficiently common and automated to vow to change into helpful for widespread functions.