RNA Fluorescence Imaging by Synthetic Nucleic Acids

June 17, 2021
Enzyme, miRNA, Polyclonal, precipitation, primers

Bis(phenylethynyl)arene Linkers in Tetracationic bis-Triarylborane Chromophores Management Fluorimetric and Raman Sensing of Numerous DNA and RNA

 

We report Four new luminescent tetracationic bis-triarylborane DNA and RNA sensors that present excessive binding affinities, in a number of instances even within the nM vary. Three of the compounds comprise substituted, extremely emissive, and structurally versatile bis(2,6-dimethylphenyl-4-ethynyl)arene linkers (3: arene=5,5′-2,2′-bithiophene; 4: arene=1,4-benzene; 5: arene=9,10-anthracene) between the 2 boryl moieties and function environment friendly twin Raman and fluorescence chromophores.

The shorter analogue 6 employs bis(2,6-dimethylphenyl)-9,10-anthracene because the linker and demonstrates the significance of an satisfactory linker size with a sure degree of flexibility by exhibiting typically decrease binding affinities than 3-5. Pronounced aggregation-deaggregation processes are noticed in fluorimetric titration experiments with DNA for compounds Three and 5. Molecular modelling of complexes of 5 with AT-DNA, counsel the minor groove because the dominant binding web site for monomeric 5, however exhibit that dimers of 5 can be accommodated. Sturdy SERS responses for 3-5 vs. a really weak response for six, notably the robust indicators from anthracene itself noticed for five however not for six, exhibit the significance of triple bonds for robust Raman exercise in molecules of this compound class.

The vitality of the attribute stretching vibration of the C≡C bonds is considerably depending on the fragrant moiety between the triple bonds. The insertion of fragrant moieties between two C≡C bonds thus presents another design for twin Raman and fluorescence chromophores, relevant in multiplex organic Raman imaging

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DNA / RNA Damage Antibody
abx444253-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx444534-100ug 100 ug
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DNA / RNA Damage Antibody
abx444884-100l 100 µl
EUR 337.5

DNA / RNA Damage Antibody
20-abx444884
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  • 25 ug
  • 100 ug

DNA / RNA Damage Antibody
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EUR 661.2

DNA / RNA Damage Antibody
abx440321-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
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EUR 661.2

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abx440883-100ug 100 ug
EUR 661.2

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EUR 661.2

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EUR 661.2

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EUR 661.2

DNA / RNA Damage Antibody
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EUR 661.2

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DNA / RNA Damage Antibody
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EUR 265

DNA/RNA Damage Antibody
MBS8001907-5x0025mg 5x0.025mg
EUR 925

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EUR 415

DNA/RNA Damage Antibody
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EUR 1595

DNA/RNA Damage Antibody
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EUR 214.2
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

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Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

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Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

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Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

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EUR 248.5
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (FITC)
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Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

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EUR 250.6
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (Biotin)
abx442850-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: Biotin
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EUR 247.8
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (ATTO390)
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EUR 587.5

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EUR 252
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

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EUR 251.3
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

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EUR 251.3
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody, Clone 15A3
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EUR 144
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

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EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 565.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A633 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 633.

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SMC-155D-A655 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 655.

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EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 680.

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Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 700.

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Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC/Cy7.

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EUR 471.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 350.

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SMC-155D-DY405 0.1mg
EUR 457.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 405.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY488 0.1mg
EUR 445.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 488.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY594 0.1mg
EUR 447.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 594.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY633 0.1mg
EUR 441.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 633.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-P594 0.1mg
EUR 462
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PE/ATTO 594.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-STR 0.1mg
EUR 451.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Streptavidin.

8-OHdG (DNA/RNA Damage) polyclonal antibody
BS66180 50ul
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Description: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

DNA/RNA Damage Antibody, Clone 15A3: Alkaline Phosphatase
SMC-155D-ALP 0.1mg
EUR 352
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Alkaline Phosphatase.

DNA/RNA Oxidative Damage
MBS605402-0025mg 0.025mg
EUR 455

DNA/RNA Oxidative Damage
MBS605402-01mg 0.1mg
EUR 675

DNA/RNA Oxidative Damage
MBS605402-5x01mg 5x0.1mg
EUR 2880

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody
12503 100ug
EUR 230

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody
12503-100 100ug
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Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody
12503-500 500ug
EUR 460

DNA and RNA Oxidative Damage Markers Monoclonal Antibody
MBS190121-01mg 0.1mg
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DNA and RNA Oxidative Damage Markers Monoclonal Antibody
MBS190121-5x01mg 5x0.1mg
EUR 1900

Anti-8-hydroxyguanosine DNA/RNA Oxidative Damage Mouse Monoclonal Antibody
12501 100ug
EUR 380

8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)
AS10-708-100 100 µg
EUR 439

8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)
AS10-708-25 25 µg
EUR 223

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx002127-100l 100 µl
EUR 400

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx002127-20l 20 µl
EUR 175

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx002127-50l 50 µl
EUR 275

DNA Damage-Binding Protein 2 (DDB2) Antibody
abx001528-100l 100 µl
EUR 400

DNA Damage-Binding Protein 2 (DDB2) Antibody
abx001528-20l 20 µl
EUR 175

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EUR 275

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159468-100g 100 µg Ask for price

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abx159468-10g 10 µg
EUR 437.5

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DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159469-100g 100 µg Ask for price

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159469-10g 10 µg
EUR 437.5

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DNA Damage-Binding Protein 2 (DDB2) Antibody
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DNA Damage-Binding Protein 2 (DDB2) Antibody
abx338922-50l 50 µl
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DNA Damage-Binding Protein 1 (DDB1) Antibody
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20-abx333999
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DNA Damage-Binding Protein 1 (DDB1) Antibody
abx333999-20g 20 µg
EUR 162.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx333999-50g 50 µg
EUR 250

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx242438-96tests 96 tests
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abx242444-96tests 96 tests
EUR 250

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx232284-100g 100 µg
EUR 350

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abx232284-100ug 100 ug
EUR 577.2

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abx402261-100tests 100 tests
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DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx010557-100g 100 µg Ask for price

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx010557-10g 10 µg
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DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx010559-100g 100 µg
EUR 387.5

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
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EUR 300

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abx010559-200g 200 µg Ask for price

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx004988-100l 100 µl
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DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx004988
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DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx004988-20l 20 µl
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DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx004988-50l 50 µl
EUR 275

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx026524-400l 400 µl
EUR 518.75

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx026524-400ul 400 ul
EUR 627.6

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx026524-80l 80 µl
EUR 281.25

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx027183-400l 400 µl
EUR 518.75

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx027183-400ul 400 ul
EUR 627.6

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx027183-80l 80 µl
EUR 250

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DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx000607
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DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx000607-20l 20 µl
EUR 175

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx000607-50l 50 µl
EUR 275

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abx112119-100l 100 µl
EUR 612.5

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx112119
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DNA Damage Inducible Transcript 4 (DDIT4) Antibody
abx112120-100l 100 µl
EUR 612.5

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
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DNA Damage Inducible Transcript 4 (DDIT4) Antibody
abx123209-100l 100 µl
EUR 200

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
20-abx123209
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DNA Damage Inducible Transcript 4 (DDIT4) Antibody
abx123209-1ml 1 ml
EUR 475

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
abx123209-200l 200 µl
EUR 325

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx129884-100l 100 µl
EUR 275

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx129884
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  • 10 ug
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DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx129884-1ml 1 ml
EUR 775

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx129884-200l 200 µl
EUR 350

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx103576-100g 100 µg
EUR 750

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx103576
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  • 10 ug
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DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx103576-20g 20 µg
EUR 275

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx103576-50g 50 µg
EUR 337.5

DNA Damage Inducible Transcript 4 (DDIT4) Antibody
abx032764-400l 400 µl
EUR 518.75

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abx032764-80l 80 µl
EUR 281.25

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx176186
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  • 200 ug
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DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx125748-100l 100 µl
EUR 175

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx125748
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DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx125748-1ml 1 ml
EUR 400

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx125748-200l 200 µl
EUR 275

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx125750-100l 100 µl
EUR 175

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx125750
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  • 20 ul
  • 50 ul
  • 100 ul
  • 200 ul

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx125750-1ml 1 ml
EUR 400

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx125750-200l 200 µl
EUR 275

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx329652-100g 100 µg Ask for price

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
20-abx329652
  • Ask for price
  • Ask for price
  • 50 ug
  • 100 ug

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx329652-20g 20 µg
EUR 187.5

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx329652-50g 50 µg
EUR 250

DNA Damage Inducible Transcript 3 (DDIT3) Antibody
abx332226-100ul 100 ul
EUR 510

 

DNA/RNA Fluorescence Imaging by Artificial Nucleic Acids

 

Fluorescence imaging of nucleic acids is a key expertise wanted to know gene expression and the ensuing adjustments in mobile operate. This chapter focuses on sequence-specific fluorescence imaging of nucleic acids in cells utilizing fluorescent nucleic acids. The design and preparation of fluorescent nucleic acids and their utility to fluorescence imaging of intracellular nucleic acids are launched.

Staphylococcus aureus membrane vesicles comprise immunostimulatory DNA, RNA and peptidoglycan that activate innate immune receptors and induce autophagy

 

Gram-positive micro organism ubiquitously produce membrane vesicles (MVs), and though they contribute to organic capabilities, our data concerning their composition and immunogenicity stays restricted. Right here we study the morphology, contents and immunostimulatory capabilities of MVs produced by three Staphylococcus aureus strains; a methicillin resistant scientific isolate, a methicillin delicate scientific isolate and a laboratory-adapted pressure. We noticed variations in the quantity and morphology of MVs produced by every pressure and confirmed that they comprise microbe-associated molecular patterns (MAMPs) together with protein, nucleic acids and peptidoglycan. Evaluation of MV-derived RNA indicated the presence of small RNA (sRNA). Moreover, we detected variability within the quantity and composition of protein, nucleic acid and peptidoglycan cargo carried by MVs from every S. aureus pressure. S. aureus MVs activated Toll-like receptor (TLR) 2, 7, 8, 9 and nucleotide-binding oligomerization area containing protein 2 (NOD2) signalling and promoted cytokine and chemokine launch by epithelial cells, thus figuring out that MV-associated MAMPs together with DNA, RNA and peptidoglycan are detected by sample recognition receptors (PRRs).

Furthermore, S. aureus MVs induced the formation of and colocalized with autophagosomes in epithelial cells, whereas inhibition of lysosomal acidification utilizing bafilomycin A1 resulted in accumulation of autophagosomal puncta that colocalized with MVs, revealing the power of the host to degrade MVs by way of autophagy. This research reveals the power of DNA, RNA and peptidoglycan related to MVs to activate PRRs in host epithelial cells, and their intracellular degradation by way of autophagy. These findings advance our understanding of the immunostimulatory roles of Gram-positive bacterial MVs in mediating pathogenesis, and their intracellular destiny inside the host.

Yeasts as a promising supply platform for DNA and RNA vaccines

 

Yeasts are thought of a helpful system for the event of vaccines for human and veterinary well being. Species reminiscent of Saccharomyces cerevisiae and Pichia pastoris have been used efficiently as host organisms for the manufacturing of subunit vaccines. These organisms have been additionally explored as vaccine autos enabling the supply of antigens reminiscent of proteins and nucleic acids. The employed species possess a GRAS standing (Typically Acknowledged as Protected) for the manufacturing of therapeutic proteins, in addition to selling immunostimulation as a result of properties of their wall cell composition.

This technique permits the administration of nucleic acids orally and a selected supply to skilled antigen-presenting cells (APCs). On this assessment, we search to stipulate the event of entire yeast vaccines (WYV) carrying nucleic acids in several approaches within the medical area, in addition to the immunological features of this vaccine technique. The info offered right here reveal the appliance of this platform in selling efficient immune responses within the context of prophylactic and therapeutic approaches.

Nonadiabatic Absorption Spectra and Ultrafast Dynamics of DNA and RNA Photoexcited Nucleobases

 

We have now not too long ago proposed a protocol for Quantum Dynamics (QD) calculations, which relies on a parameterisation of Linear Vibronic Coupling (LVC) Hamiltonians with Time Dependent (TD) Density Purposeful Principle (TD-DFT), and exploits the most recent developments in multiconfigurational TD-Hartree strategies for an efficient wave packet propagation. On this contribution we discover the potentialities of this method to compute nonadiabatic vibronic spectra and ultrafast dynamics, by making use of it to the 5 nucleobases current in DNA and RNA. For all of them we computed the absorption spectra and the dynamics of ultrafast inner conversion (100 fs timescale), totally coupling the primary 2-Three shiny states and all of the shut by darkish states, for a complete of 6-9 states, and together with all the traditional coordinates.

We adopted two completely different functionals, CAM-B3LYP and PBE0, and examined the impact of the idea set. Computed spectra are in good settlement with the obtainable experimental information, remarkably bettering over pure digital computations, but additionally with respect to vibronic spectra obtained neglecting inter-state couplings. Our QD simulations point out an efficient inhabitants switch from the bottom vitality shiny excited states to the close-lying darkish excited states for uracil, thymine and adenine. Dynamics from higher-energy states present an ultrafast depopulation towards the extra steady ones. The proposed protocol is sufficiently common and automated to vow to change into helpful for widespread functions.

 

 

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