Multicolor single-molecule FRET for DNA and RNA processes

May 21, 2021
Enzyme, Isotype, miRNA, Polyclonal

Position of bacterial RNA polymerase gate opening dynamics in DNA loading and antibiotics inhibition elucidated by quasi-Markov State Mannequin

 

To provoke transcription, the holoenzyme (RNA polymerase [RNAP] in complicated with σ issue) masses the promoter DNA through the versatile loading gate created by the clamp and β-lobe, but their roles in DNA loading haven’t been characterised.

We used a quasi-Markov State Mannequin (qMSM) constructed from in depth molecular dynamics simulations to elucidate the dynamics of Thermus aquaticus holoenzyme’s gate opening. We confirmed that in gate opening, β-lobe oscillates 4 orders of magnitude sooner than the clamp, whose opening relies on the Change 2’s construction. Myxopyronin, an antibiotic that binds to Change 2, was proven to bear a conformational choice mechanism to inhibit clamp opening.

Importantly, we reveal a important however undiscovered position of β-lobe, whose opening is adequate for DNA loading even when the clamp is partially closed. These findings open the chance for the event of antibiotics focusing on β-lobe of RNAP. Lastly, we’ve proven that our qMSMs, which encode non-Markovian dynamics primarily based on the generalized grasp equation formalism, maintain nice potential to be broadly utilized to check biomolecular dynamics.

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bio-tech-inc

DNA / RNA Damage Antibody
abx440883-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx443410-100ug 100 ug
EUR 644.4

DNA / RNA Damage Antibody
abx443691-100ug 100 ug
EUR 678

DNA / RNA Damage Antibody
abx443972-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx444253-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx444534-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx444884-100l 100 µl
EUR 337.5

DNA / RNA Damage Antibody
20-abx444884
  • Ask for price
  • Ask for price
  • 25 ug
  • 100 ug

DNA / RNA Damage Antibody
abx442007-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx442288-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx442569-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx442850-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx443130-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx441164-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx441445-100ug 100 ug
EUR 661.2

DNA / RNA Damage Antibody
abx441726-100ug 100 ug
EUR 661.2

DNA/RNA Damage Antibody
MBS801590-01mg 0.1mg
EUR 415

DNA/RNA Damage Antibody
MBS801590-5x01mg 5x0.1mg
EUR 1595

DNA/RNA Damage Antibody
MBS8001907-0025mg 0.025mg
EUR 265

DNA/RNA Damage Antibody
MBS8001907-5x0025mg 5x0.025mg
EUR 925

DNA/RNA Damage Antibody
SMC-155D 0.1mg
EUR 214.2
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody
SMC-155S 0.012mg Ask for price
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (PE)
abx444253-100g 100 µg
EUR 575

DNA / RNA Damage Antibody (HRP)
abx443410-100g 100 µg
EUR 562.5

DNA / RNA Damage Antibody (APC)
abx442569-100l 100 µl
EUR 575

DNA/RNA Damage Antibody: HRP
MBS801864-01mg 0.1mg
EUR 450

DNA/RNA Damage Antibody: HRP
MBS801864-5x01mg 5x0.1mg
EUR 1770

DNA/RNA Damage Antibody: RPE
MBS803622-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: RPE
MBS803622-5x01mg 5x0.1mg
EUR 1820

DNA/RNA Damage Antibody: APC
SMC-155D-APC 0.1mg
EUR 250.6
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody: HRP
SMC-155D-HRP 0.1mg
EUR 241.5
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody: RPE
SMC-155D-RPE 0.1mg
EUR 248.5
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (FITC)
abx443130-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: FITC
MBS803261-01mg 0.1mg
EUR 455

DNA/RNA Damage Antibody: FITC
MBS803261-5x01mg 5x0.1mg
EUR 1790

DNA/RNA Damage Antibody: FITC
SMC-155D-FITC 0.1mg
EUR 245
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (PerCP)
abx443972-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: PerCP
MBS802697-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: PerCP
MBS802697-5x01mg 5x0.1mg
EUR 1830

DNA/RNA Damage Antibody: PerCP
SMC-155D-PCP 0.1mg
EUR 250.6
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (Biotin)
abx442850-100g 100 µg
EUR 575

DNA/RNA Damage Antibody: Biotin
MBS803145-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: Biotin
MBS803145-5x01mg 5x0.1mg
EUR 1815

DNA/RNA Damage Antibody: Biotin
SMC-155D-BI 0.1mg
EUR 247.8
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA / RNA Damage Antibody (ATTO390)
abx440040-200g 200 µg
EUR 587.5

DNA / RNA Damage Antibody (ATTO488)
abx440321-100g 100 µg
EUR 587.5

DNA / RNA Damage Antibody (ATTO594)
abx440883-100g 100 µg
EUR 587.5

DNA/RNA Damage Antibody: ATTO 594
MBS800732-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 594
MBS800732-5x01mg 5x0.1mg
EUR 1835

DNA/RNA Damage Antibody: ATTO 390
MBS802627-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 390
MBS802627-5x01mg 5x0.1mg
EUR 1840

DNA/RNA Damage Antibody: ATTO 488
MBS804277-01mg 0.1mg
EUR 465

DNA/RNA Damage Antibody: ATTO 488
MBS804277-5x01mg 5x0.1mg
EUR 1835

DNA/RNA Damage Antibody: ATTO 390
SMC-155D-A390 0.1mg
EUR 252
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody: ATTO 488
SMC-155D-A488 0.1mg
EUR 251.3
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody: ATTO 594
SMC-155D-A594 0.1mg
EUR 251.3
Description: Mouse Anti- DNA/RNA Damage Monoclonal IgG2b

DNA/RNA Damage Antibody, Clone 15A3
SMC-155C 0.025mg
EUR 144
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

OASE00080-25UG - DNA/RNA Damage Antibody
OASE00080-25UG 25ug
EUR 199

OASE00081-100UG - DNA/RNA Damage Antibody
OASE00081-100UG 100ug
EUR 399

DNA/RNA Damage Antibody: Alkaline Phosphatase
MBS800170-01mg 0.1mg
EUR 460

DNA/RNA Damage Antibody: Alkaline Phosphatase
MBS800170-5x01mg 5x0.1mg
EUR 1800

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A565 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 565.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A633 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 633.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A655 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 655.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A680 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 680.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A700 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 700.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-APCCY7 0.1mg
EUR 540
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC/Cy7.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY350 0.1mg
EUR 471.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 350.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY405 0.1mg
EUR 457.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 405.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY488 0.1mg
EUR 445.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 488.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY594 0.1mg
EUR 447.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 594.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY633 0.1mg
EUR 441.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 633.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-P594 0.1mg
EUR 462
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PE/ATTO 594.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-STR 0.1mg
EUR 451.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Streptavidin.

8-OHdG (DNA/RNA Damage) polyclonal antibody
BS66180 50ul
EUR 358
Description: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

DNA/RNA Damage Antibody, Clone 15A3: Alkaline Phosphatase
SMC-155D-ALP 0.1mg
EUR 352
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Alkaline Phosphatase.

DNA/RNA Oxidative Damage
MBS605402-0025mg 0.025mg
EUR 455

DNA/RNA Oxidative Damage
MBS605402-01mg 0.1mg
EUR 675

DNA/RNA Oxidative Damage
MBS605402-5x01mg 5x0.1mg
EUR 2880

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody
12503 100ug
EUR 230

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody
12503-100 100ug
EUR 230

Anti-8-Oxo-A DNA/RNA Damage Mouse Monoclonal Antibody
12503-500 500ug
EUR 460

DNA and RNA Oxidative Damage Markers Monoclonal Antibody
MBS190121-01mg 0.1mg
EUR 425

DNA and RNA Oxidative Damage Markers Monoclonal Antibody
MBS190121-5x01mg 5x0.1mg
EUR 1900

Anti-8-hydroxyguanosine DNA/RNA Oxidative Damage Mouse Monoclonal Antibody
12501 100ug
EUR 380

8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)
AS10-708-100 100 µg
EUR 439

8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)
AS10-708-25 25 µg
EUR 223

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx242438-96tests 96 tests
EUR 250

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx242444-96tests 96 tests
EUR 250

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx232284-100g 100 µg
EUR 350

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx232284-100ug 100 ug
EUR 577.2

DNA damage-binding protein 2 (DDB2) Antibody
abx402261-100tests 100 tests
EUR 287.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx333999-100g 100 µg
EUR 362.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
20-abx333999
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 20 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx333999-20g 20 µg
EUR 162.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx333999-50g 50 µg
EUR 250

DNA Damage-Binding Protein 2 (DDB2) Antibody
abx338922-100l 100 µl
EUR 250

DNA Damage-Binding Protein 2 (DDB2) Antibody
20-abx338922
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  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 20 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

DNA Damage-Binding Protein 2 (DDB2) Antibody
abx338922-50l 50 µl
EUR 162.5

DNA Damage-Binding Protein 1 (DDB1) Antibody
abx159468-100g 100 µg Ask for price

Multicolor single-molecule FRET for DNA and RNA processes

Single-molecule fluorescence resonance power switch (smFRET) is a great tool for observing the dynamics of protein-nucleic acid interactions. Though most smFRET measurements have used two fluorophores, multicolor smFRET measurements utilizing greater than two fluorophores provide extra details about how protein-nucleic acid complexes dynamically transfer, assemble, and disassemble.

Multicolor smFRET experiments embody three or extra fluorophores and at the least one donor-acceptor pair. This assessment highlights how multicolor smFRET is getting used to probe the dynamics of three completely different lessons of biochemical processes-protein-DNA interactions, chromatin transforming, and protein translation.

Phenoxazine nucleoside derivatives with a a number of exercise in opposition to RNA and DNA viruses

Rising and re-emerging viruses periodically trigger outbreaks and epidemics everywhere in the world, ultimately resulting in international occasions resembling the present pandemic of the novel SARS-CoV-2 coronavirus an infection COVID-19. Subsequently, an pressing want for novel antivirals is crystal clear.

Right here we current the synthesis and analysis of an antiviral exercise of phenoxazine-based nucleoside analogs divided into three teams: (1) 8-alkoxy-substituted, (2) acyclic, and (3) carbocyclic. The antiviral exercise was assessed in opposition to a structurally and phylogenetically various panel of RNA and DNA viruses from 25 species.

4 compounds (11a-c, 12c) inhibited four DNA/RNA viruses with EC50 ≤ 20 μM. Toxicity of the compounds for the cell traces used for virus cultivation was negligible generally. As well as, beforehand reported and newly synthesized phenoxazine derivatives have been evaluated in opposition to SARS-CoV-2, and a few of them confirmed promising inhibition of copy with EC50 values in low micromolar vary, though accompanied by commensurate cytotoxicity.

 

 

In Silico screening of circulating tumor DNA, circulating microRNAs, and lengthy non-coding RNAs as diagnostic molecular biomarkers in ovarian most cancers: A complete meta-analysis

 

Background: Ovarian most cancers (OC) is a number one reason behind demise in gynecological malignancies worldwide. Multitudinous research have steered the potential of circulating tumor DNA (ctDNA), circulating microRNAs (miRNAs), and lengthy non-coding RNAs (lncRNAs) as novel diagnostic molecular biomarkers for OC. Right here, we embody three up to date meta-analysis strategies utilizing completely different molecular biomarkers to guage their discriminative worth in OC prognosis.

 

Strategies: We carried out three meta-analyses after looking completely different databases, and 23 eligible articles, together with Eight regarding ctDNA, 11 regarding miRNAs, and four regarding lncRNAs, have been discovered. Additional, we pooled information regarding the sensitivity, specificity, and different indicators of accuracy for ctDNA/miRNAs/lncRNAs within the prognosis of OC. The heterogeneity was additional explored by meta-regressions and subgroup analyses, and Deeks’ funnel plots have been used to measure the publication bias of those three meta-analyses.

 

Outcomes: In all, this meta-analysis included 1732 OC sufferers and 3958 controls. The sensitivity of ctDNA for OC prognosis was superior to that of lncRNA and miRNA (84% vs. 81% vs. 78%). Furthermore, the specificity and space below the receiver-operating attribute (ROC) curve (AUC) of ctDNA have been 91% and 94%, which have been considerably larger than these of miRNA and lncRNAs (78% and 85%; 78% and 86%, respectively). No vital distinction was noticed among the many two meta-analyses of ctDNA and lncRNA (P > 0.05) with regard to publication bias, whereas the meta-analysis of miRNA noticed a considerably small publication bias (P < 0.05).

 

Conclusion: ctDNA/miRNAs/lncRNAs could also be promising molecular biomarkers for OC prognosis. Additional large-scale research are wanted to confirm the potential applicability of ctDNA/miRNAs/lncRNAs molecular signatures alone or together as diagnostic molecular biomarkers for OC.

 

Circulating plasma tumor DNA is superior to plasma tumor RNA detection in Ewing sarcoma sufferers

 

The detection of tumor-specific nucleic acids from blood is being more and more used as a technique of liquid biopsy and minimal residual illness detection. Nevertheless, reaching excessive sensitivity and excessive specificity stays a problem.

Right here, we carry out a direct comparability of two droplet digital PCR (ddPCR)-based detection strategies, circulating plasma tumor RNA (ptRNA) and circulating plasma tumor DNA (ptDNA), in blood samples from newly recognized Ewing sarcoma sufferers. First, we developed three particular ddPCR-based assays to detect EWS-ETS fusion transcripts, which naturally demonstrated superior sensitivity to DNA detection on in vitro management samples.

Subsequent, we recognized the patient-specific EWS-ETS breakpoint from 5 affected person tumor samples and designed ddPCR-based patient-specific ptDNA assays for every affected person. These patient-specific assays display that, whereas ptRNA might be detected in choose newly recognized sufferers, optimistic outcomes are low and statistically unreliable in comparison with ptDNA assays, which reproducibly detect sturdy optimistic outcomes throughout most sufferers.

Moreover, the distinctive illness biology of Ewing sarcoma enabled us to display that the majority cell-free RNA isn’t tumor-derived, whereas cell-free-DNA burden is strongly affected by tumor-derived DNA burden. Right here, we conclude that, even with optimized extremely delicate and particular assays, tumor DNA detection is superior to RNA detection in Ewing sarcoma sufferers.

 

Reverse roles of transcription elongation elements Spt4/5 and Elf1 in RNA polymerase II transcription via B-form versus non-B DNA buildings

Transcription elongation might be affected by quite a few varieties of obstacles, resembling nucleosome, pausing sequences, DNA lesions and non-B-form DNA buildings. Spt4/5 and Elf1 are conserved transcription elongation elements that promote RNA polymerase II (Pol II) bypass of nucleosome and pausing sequences. Importantly, genetic research have proven that Spt4/5 performs important roles within the transcription of expanded nucleotide repeat genes related to inherited neurological illnesses.

Right here, we examine the perform of Spt4/5 and Elf1 within the transcription elongation of CTG•CAG repeat utilizing an in vitro reconstituted yeast transcription system. We discovered that Spt4/5 helps Pol II transcribe via the CTG•CAG tract duplex DNA, which is in good settlement with its canonical roles in stimulating transcription elongation. In sharp distinction, surprisingly, we revealed that Spt4/5 enormously inhibits Pol II transcriptional bypass of CTG and CAG slip-out buildings.

Moreover, we demonstrated that transcription elongation issue Elf1 individually and cooperatively with Spt4/5 inhibits Pol II bypass of the slip-out buildings. This examine uncovers the necessary useful interplays between template DNA buildings and the perform of transcription elongation elements. This examine additionally expands our understanding of the features of Spt4/5 and Elf1 in transcriptional processing of trinucleotide repeat DNA.

 

8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)
AS10-708-100 100 µg
EUR 439

8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)
AS10-708-25 25 µg
EUR 223

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A565 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 565.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A633 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 633.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A655 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 655.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A680 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 680.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-A700 0.1mg
EUR 453.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 700.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-APCCY7 0.1mg
EUR 540
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC/Cy7.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY350 0.1mg
EUR 471.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 350.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY405 0.1mg
EUR 457.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 405.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY488 0.1mg
EUR 445.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 488.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY594 0.1mg
EUR 447.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 594.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-DY633 0.1mg
EUR 441.6
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 633.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-P594 0.1mg
EUR 462
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PE/ATTO 594.

Monoclonal antibody for DNA/RNA Damage
SMC-155D-STR 0.1mg
EUR 451.2
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Streptavidin.

Anti-8-hydroxyguanosine DNA/RNA Oxidative Damage Mouse Monoclonal Antibody
12501 100ug
EUR 380

Mouse Anti-Gliadin IgG2b Monoclonal Antibody, Clone 3A10H10
7149 1 mg/ml x 0.1 ml
EUR 238

DNA and RNA Oxidative Damage Markers Monoclonal Antibody
MBS190121-01mg 0.1mg
EUR 425

DNA and RNA Oxidative Damage Markers Monoclonal Antibody
MBS190121-5x01mg 5x0.1mg
EUR 1900

TRIM38 Mouse Monoclonal Antibody [Clone:15A3]
E45M13597 100 ug
EUR 595

TRIM38 Mouse Monoclonal Antibody [Clone 15A3]
E45M13597V-2 50 ul
EUR 195

Mouse Monoclonal [clone 8A1] (IgG2b) to Human CD105
MBS249075-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone 8A1] (IgG2b) to Human CD105
MBS249075-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone 3A1] (IgG2b,k) to Human SF3B4
MBS249004-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone 3A1] (IgG2b,k) to Human SF3B4
MBS249004-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone 5A6] (IgG2b) to Human LRP1 / CD91
MBS245425-005mg 0.05mg
EUR 680

Mouse Monoclonal [clone 5A6] (IgG2b) to Human LRP1 / CD91
MBS245425-5x005mg 5x0.05mg
EUR 2875

Mouse Anti-HDM IgG2b Monoclonal Antibody, Clone 3C4H2
7112 1 mg/ml x 0.1 ml
EUR 238
Description: Mouse Anti-HDM IgG2b Monoclonal Antibody

ST2 (IL1RL1) Mouse Monoclonal Antibody [Clone:15A3]
E45M19401 100 ug
EUR 595

ST2 (IL1RL1) Mouse Monoclonal Antibody [Clone 15A3]
E45M19401V-2 50 ul
EUR 195

Mouse Anti-SEB IgG2b Monoclonal Antibody, Clone 5D12C9
7105 1 mg/ml x 0.1 ml
EUR 321
Description: Mouse Anti-SEB IgG2b Monoclonal Antibody

Mouse Anti-SEA IgG2b Monoclonal Antibody, Clone 1E10G12
7108 1 mg/ml x 0.1 ml
EUR 321
Description: Mouse Anti-SEA IgG2b Monoclonal Antibody

Mouse Anti-Ro60 IgG2b Monoclonal Antibody, Clone 2D6E12
7125 1 mg/ml x 0.1 ml
EUR 238
Description: Mouse Anti-Ro60 IgG2b Monoclonal Antibody

Mouse Monoclonal [clone S60-4] (IgG2b)
MBS246001-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone S60-4] (IgG2b)
MBS246001-5x005mg 5x0.05mg
EUR 2500

Mouse Anti-Ovalbumin IgG2b Monoclonal Antibody, Clone 4B4E6
7096 1 mg/ml x 0.1 ml
EUR 238
Description: Mouse Anti-Ovalbumin IgG2b Monoclonal Antibody

Mouse Monoclonal [clone 2A5] (IgG2b) to Human ACTB / Beta Actin
MBS246504-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone 2A5] (IgG2b) to Human ACTB / Beta Actin
MBS246504-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal Anti-Rat CD134, PE (Clone OX40) (mouse IgG2b)
RCD134-PE 100 tests
EUR 562.8

Mouse Monoclonal [clone 2A3] (IgG2b) to Human ACTG1 / Gamma Actin
MBS246374-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone 2A3] (IgG2b) to Human ACTG1 / Gamma Actin
MBS246374-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal Anti-Rat CD134, FITC (Clone OX40) (mouse IgG2b)
RCD134-F 100 tests
EUR 562.8

Mouse Anti-Mouse PD-L1 IgG2b Monoclonal Antibody, Clone 3H9G2
7134 2 mg/ml x 5.0 ml
EUR 524

Mouse Monoclonal Anti-Rat CD134, Biotin (Clone OX40) (mouse IgG2b)
RCD134-B 100 tests
EUR 562.8

Mouse Monoclonal Anti-Rat CD134, Purified (Clone OX40) (mouse IgG2b)
RCD134-M 100 tests
EUR 578.4

Rat IgG2b (Gamma-2b chain specific) mouse monoclonal antibody, clone 2B 10A8, AP
AM08093AP-N 1 ml Ask for price

Rat IgG2b (Gamma-2b chain specific) mouse monoclonal antibody, clone 2B 10A8, Cy5
AM08093C5-N 100 µg Ask for price

Rat IgG2b (Gamma-2b chain specific) mouse monoclonal antibody, clone 2B 10A8, HRP
AM08093HR-N 1 ml Ask for price

Rat IgG2b (Gamma-2b chain specific) mouse monoclonal antibody, clone 2B 10A8, PE
AM08093RP-N 100 µg Ask for price

Mouse Monoclonal Anti-Mouse CD5 (Ly 1.2), PE (Clone CG16) (mouse IgG2b)
MCD005-PE 100 tests
EUR 562.8

Mouse Monoclonal [clone 40101] (IgG2b) to Human IL1RA
MBS245457-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone 40101] (IgG2b) to Human IL1RA
MBS245457-5x005mg 5x0.05mg
EUR 2500

Rat IgG2b (Gamma-2b chain specific) mouse monoclonal antibody, clone 2B 10A8, BIMA
AM08093BT-N 500 µg Ask for price

Rat IgG2b (Gamma-2b chain specific) mouse monoclonal antibody, clone 2B 10A8, FITC
AM08093FC-N 500 µg Ask for price

Mouse Monoclonal Anti-Mouse CD5 (Ly 1.2), FITC (Clone CG16) (mouse IgG2b)
MCD005-F 100 tests
EUR 562.8

Mouse Monoclonal Anti-Mouse CD5 (Ly 1.2), Biotin (Clone CG16) (mouse IgG2b)
MCD005-B 100 tests
EUR 562.8

Mouse Monoclonal [clone K1C12] (IgG2b,k) to Human UNG / Uracil DNA Glycosylase
MBS245335-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone K1C12] (IgG2b,k) to Human UNG / Uracil DNA Glycosylase
MBS245335-5x005mL 5x0.05mL
EUR 2500

Mouse Anti-E. coli and LPS IgG2b Monoclonal Antibody, Clone 2H10
7100 1 mg/ml x 0.1 ml
EUR 321
Description: Mouse Anti-E. coli and LPS IgG2b Monoclonal Antibody

Rat IgG2b (Gamma-2b chain specific) mouse monoclonal antibody, clone 2B 10A8, Purified
AM08093PU-N 500 µg Ask for price

TRIM38 mouse monoclonal antibody, clone OTI15A3 (formerly 15A3)
TA505979 100 µl Ask for price

TRIM38 mouse monoclonal antibody, clone OTI15A3 (formerly 15A3)
TA505979S 30 µl Ask for price

Mouse Monoclonal [clone 51.1] (IgG2b) to Human CD1D
MBS245780-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone 51.1] (IgG2b) to Human CD1D
MBS245780-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal Anti-Mouse CD5 (Ly 1.2), No Azide (Clone CG16) (mouse IgG2b)
MCD005-M 100 Tests
EUR 578.4

Mouse Monoclonal [clone SM1] (IgG2b) to Human STAT1
MBS245125-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone SM1] (IgG2b) to Human STAT1
MBS245125-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal [clone 1G10] (IgG2b) to Human HAND1
MBS249182-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone 1G10] (IgG2b) to Human HAND1
MBS249182-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone 13D7] (IgG2b) to Human CD32A
MBS249188-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone 13D7] (IgG2b) to Human CD32A
MBS249188-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone R4.5] (IgG2b) to Rat GNAI1 / Gi
MBS245273-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone R4.5] (IgG2b) to Rat GNAI1 / Gi
MBS245273-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone GF-01] (IgG2b) to Pig GFAP
MBS246538-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone GF-01] (IgG2b) to Pig GFAP
MBS246538-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal [clone 2B3] (IgG2b,k) to Human MYH9
MBS245601-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone 2B3] (IgG2b,k) to Human MYH9
MBS245601-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal [clone 4H3] (IgG2b,k) to Human MYH9
MBS246480-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone 4H3] (IgG2b,k) to Human MYH9
MBS246480-5x005mg 5x0.05mg
EUR 2500

Anti-Mouse IgG2b Rabbit Monoclonal Antibody, Clone#RM108
M33092 100ug
EUR 431
Description: Boster Bio Anti-Mouse IgG2b Rabbit Monoclonal Antibody, Clone#RM108 (Catalog # M33092). Tested in ELISA, WB applications. This antibody reacts with Mouse.

Mouse Monoclonal [clone TFG-03] (IgG2b) to Human TFG
MBS249011-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone TFG-03] (IgG2b) to Human TFG
MBS249011-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal [clone 5C10] (IgG2b,k) to Human CD44
MBS245492-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone 5C10] (IgG2b,k) to Human CD44
MBS245492-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone AT2F6] (IgG2b,k) to Human G6PD
MBS245347-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone AT2F6] (IgG2b,k) to Human G6PD
MBS245347-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone AT1F2] (IgG2b,k) to Human TDP1
MBS245414-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone AT1F2] (IgG2b,k) to Human TDP1
MBS245414-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone AT3B2] (IgG2b,k) to Human MYL2
MBS245437-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone AT3B2] (IgG2b,k) to Human MYL2
MBS245437-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone AT2G11] (IgG2b,k) to Human RAC2
MBS249015-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone AT2G11] (IgG2b,k) to Human RAC2
MBS249015-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone 76B357.1] (IgG2b,k) to Human TLR4
MBS245186-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone 76B357.1] (IgG2b,k) to Human TLR4
MBS245186-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal [clone K1H3] (IgG2b,k) to Human UBE2L6
MBS245393-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone K1H3] (IgG2b,k) to Human UBE2L6
MBS245393-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone AT3A2] (IgG2b,k) to Human MAT2A
MBS245410-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone AT3A2] (IgG2b,k) to Human MAT2A
MBS245410-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone 4K5F6] (IgG2b,k) to Human IL17A
MBS246549-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone 4K5F6] (IgG2b,k) to Human IL17A
MBS246549-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal [clone D1C5] (IgG2b,k) to Human TPD52L1
MBS245475-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone D1C5] (IgG2b,k) to Human TPD52L1
MBS245475-5x005mL 5x0.05mL
EUR 2500

Mouse Anti-D. pteronyssinus Der p2 IgG2b Monoclonal Antibody (mAb), Clone 4C10H3
7156 1 mg/ml x 0.1 ml
EUR 246
Description: Allergy

Mouse Monoclonal [clone AT5E10] (IgG2b,k) to Human EIF2S1
MBS245582-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone AT5E10] (IgG2b,k) to Human EIF2S1
MBS245582-5x005mL 5x0.05mL
EUR 2500

Rat Monoclonal [clone M1/70.15] (IgG2b) to Mouse ITGAM / CD11b
MBS246285-005mg 0.05mg
EUR 595

Rat Monoclonal [clone M1/70.15] (IgG2b) to Mouse ITGAM / CD11b
MBS246285-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal [clone LN3] (IgG2b,k) to Human HLA-DR
MBS246481-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone LN3] (IgG2b,k) to Human HLA-DR
MBS246481-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal [clone 10.32] (IgG2b) to Human UMOD / Uromodulin
MBS245422-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone 10.32] (IgG2b) to Human UMOD / Uromodulin
MBS245422-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal [clone 10.32] (IgG2b) to Human UMOD / Uromodulin
MBS245507-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone 10.32] (IgG2b) to Human UMOD / Uromodulin
MBS245507-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal [clone 1E4] (IgG2b,k) to Human NPRB / NPR2
MBS246578-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone 1E4] (IgG2b,k) to Human NPRB / NPR2
MBS246578-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal [clone 33CT11.40.3] (IgG2b) to Human DPYSL2 / CRMP2
MBS245367-02mL 0.2mL
EUR 595

Mouse Monoclonal [clone 33CT11.40.3] (IgG2b) to Human DPYSL2 / CRMP2
MBS245367-5x02mL 5x0.2mL
EUR 2500

Mouse Monoclonal [clone PAG-C1] (IgG2b) to Human PAG1 / PAG
MBS245321-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone PAG-C1] (IgG2b) to Human PAG1 / PAG
MBS245321-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal [clone AT2T4] (IgG2b,k) to Human AGXT / SPT
MBS246127-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone AT2T4] (IgG2b,k) to Human AGXT / SPT
MBS246127-5x005mg 5x0.05mg
EUR 2500

Mouse Anti-HDM IgG2a Monoclonal Antibody, Clone 2A11C4
7127 1 mg/ml x 0.1 ml
EUR 238
Description: Mouse Anti-HDM IgG2a Monoclonal Antibody

Mouse Monoclonal [clone S4E5] (IgG2b,k) to Human SETD7 / SET7
MBS245424-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone S4E5] (IgG2b,k) to Human SETD7 / SET7
MBS245424-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone 1D8] (IgG2b,k) to Human CBFA1 / RUNX2
MBS246574-01mg 0.1mg
EUR 645

Mouse Monoclonal [clone 1D8] (IgG2b,k) to Human CBFA1 / RUNX2
MBS246574-5x01mg 5x0.1mg
EUR 2735

Mouse IgG2b Kappa Isotype Control Monoclonal Clone MPC11 PE
IMSIGG2BKICMPC11CPE100UG each
EUR 150
Description: Mouse IgG2b Kappa Isotype Control Monoclonal Clone MPC11 PE

Mouse IgG2b Kappa Isotype Control Monoclonal Clone MPC11 PE
IMSIGG2BKICMPC11CPE25UG each
EUR 55
Description: Mouse IgG2b Kappa Isotype Control Monoclonal Clone MPC11 PE

Mouse Monoclonal [clone J4B2] (IgG2b,k) to Human ACOT11 / THEA
MBS245451-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone J4B2] (IgG2b,k) to Human ACOT11 / THEA
MBS245451-5x005mL 5x0.05mL
EUR 2500

Mouse IgG2b Kappa Isotype Control Monoclonal Clone MPC11 APC
IMSIGG2BKICMPC11CAPC100UG each
EUR 150
Description: Mouse IgG2b Kappa Isotype Control Monoclonal Clone MPC11 APC

Mouse IgG2b Kappa Isotype Control Monoclonal Clone MPC11 APC
IMSIGG2BKICMPC11CAPC25UG each
EUR 55
Description: Mouse IgG2b Kappa Isotype Control Monoclonal Clone MPC11 APC

Mouse Monoclonal [clone CF-145] (IgG2b) to Human S100A8 / MRP8
MBS245035-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone CF-145] (IgG2b) to Human S100A8 / MRP8
MBS245035-5x005mg 5x0.05mg
EUR 2500

Mouse Monoclonal [clone P6C7] (IgG2b,k) to Human PP2Ac / PPP2CA
MBS245334-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone P6C7] (IgG2b,k) to Human PP2Ac / PPP2CA
MBS245334-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone J2D2] (IgG2b,k) to Human STEAP1 / STEAP
MBS245349-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone J2D2] (IgG2b,k) to Human STEAP1 / STEAP
MBS245349-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone Sarmy-1] (IgG2b) to Human SARM1 / SARM
MBS245876-005mg 0.05mg
EUR 645

Mouse Monoclonal [clone Sarmy-1] (IgG2b) to Human SARM1 / SARM
MBS245876-5x005mg 5x0.05mg
EUR 2735

Mouse Monoclonal [clone 2H4] (IgG2b,k) to Human TNFRSF18 / GITR
MBS246415-005mg 0.05mg
EUR 615

Mouse Monoclonal [clone 2H4] (IgG2b,k) to Human TNFRSF18 / GITR
MBS246415-5x005mg 5x0.05mg
EUR 2605

Mouse IgG2b Kappa Isotype Control Monoclonal Clone MPC11 FITC
IMSIGG2BKICMPC11CFITC100UG each
EUR 150
Description: Mouse IgG2b Kappa Isotype Control Monoclonal Clone MPC11 FITC

Mouse IgG2b Kappa Isotype Control Monoclonal Clone MPC11 FITC
IMSIGG2BKICMPC11CFITC25UG each
EUR 55
Description: Mouse IgG2b Kappa Isotype Control Monoclonal Clone MPC11 FITC

Mouse Anti-Mouse Interleukin 10 Receptor (IL-10RA) IgG2b Monoclonal Antibody, Clone 2E2E11
7145 1 mg/ml x 0.1 ml
EUR 238

Mouse Monoclonal [clone AT1A1] (IgG2b,k) to Human CRABP1 / CRABP
MBS245370-005mL 0.05mL
EUR 595

Mouse Monoclonal [clone AT1A1] (IgG2b,k) to Human CRABP1 / CRABP
MBS245370-5x005mL 5x0.05mL
EUR 2500

Mouse Monoclonal [clone X1] (IgG2b,k) to Human C-Kit / CD117
MBS245931-005mg 0.05mg
EUR 595

Mouse Monoclonal [clone X1] (IgG2b,k) to Human C-Kit / CD117
MBS245931-5x005mg 5x0.05mg
EUR 2500

Mouse IgG2b Kappa Isotype Control Monoclonal Clone MPC11 AF488
IMSIGG2BKICMPC11CAF488100UG each
EUR 150
Description: Mouse IgG2b Kappa Isotype Control Monoclonal Clone MPC11 AF488
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