A genome-wide screen for differentially methylated long noncoding RNAs

Systematic comparability and prediction of the consequences of missense mutations on protein-DNA and protein-RNA interactions

 The binding affinities of protein-nucleic acid interactions may very well be altered as a consequence of missense mutations occurring in DNA- or RNA-binding proteins, subsequently leading to numerous illnesses. Sadly, a scientific comparability and prediction of the consequences of mutations on protein-DNA and protein-RNA interactions (these two mutation lessons are termed MPDs and MPRs, respectively) remains to be missing. Right here, we demonstrated that these two lessons of mutations may generate comparable or completely different tendencies for binding free power adjustments when it comes to the properties of mutated residues. We then developed regression algorithms individually for MPDs and MPRs by introducing novel geometric partition-based power options and interface-based structural options.

By characteristic choice and ensemble studying, comparable computational frameworks that built-in energy- and nonenergy-based fashions had been established to estimate the binding affinity adjustments ensuing from MPDs and MPRs, however the chosen options for the remaining fashions had been completely different and subsequently mirrored the specificity of those two mutation lessons. Moreover, the proposed methodology was prolonged to the identification of mutations that considerably decreased the binding affinities. In depth validations indicated that our algorithm typically carried out higher than the state-of-the-art strategies on each the regression and classification duties. The webserver and software program are freely obtainable at PEMPNI

Optimising glyphosate tolerance in rapeseed (Brassica napus L.) by CRISPR/Cas9-based geminiviral donor DNA replicon system with Csy4-based single-guide RNA processing

 

Rapeseed (Brassica napus L.) is a crucial oil crop worldwide, and efficient weed management can defend its yields and high quality. Farmers can profit from tolerant cultivars when utilizing herbicides, equivalent to glyphosate. Amino acid substitutions in enolpyruvylshikimate-3-phosphate synthase (EPSPS) render the plant much less delicate to glyphosate. Due to this fact, we aimed to optimise the glyphosate tolerance trait in rapeseed by way of endogenous EPSPS modification. To attain efficient gene substitute in B. napus L., we employed a CRISPR/Cas9 system expressing single-guide RNAs (sgRNAs) cleaved by the CRISPR-associated RNA endoribonuclease Csy4 from Pseudomonas aeruginosa for focused induction of double-strand breaks. Each the donor template and a geminiviral replicon harbouring an sgRNA expression cassette had been launched into plant cells.

Utilizing sgRNAs focusing on adjoining donor DNA template containing synonymous mutations in sgRNA websites, we achieved exact gene replacements within the endogenous B. napus EPSPS gene, BnaC04EPSPS, leading to TIPS and LFGAAGMCRL amino acid substitutions at frequencies as much as 20%. Rapeseed seedlings harbouring EPSPSmTIPS or EPSPSmLFGAAGMCRL had been glyphosate tolerant. Moreover, modifications in BnaC04EPSPS had been exactly transmitted to the following era. Our genome enhancing technique allows extremely environment friendly gene focusing on and the induction of glyphosate tolerance in oilseed rape.

bio-tech-inc

bio-tech-inc

DNA / RNA Damage Antibody

abx441164-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

DNA / RNA Damage Antibody

abx441445-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

DNA / RNA Damage Antibody

abx441726-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

DNA / RNA Damage Antibody

abx442007-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

DNA / RNA Damage Antibody

abx442288-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

DNA / RNA Damage Antibody

abx442569-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

DNA / RNA Damage Antibody

abx442850-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

DNA / RNA Damage Antibody

abx443130-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

DNA / RNA Damage Antibody

abx443410-100ug 100 ug
EUR 537
  • Shipped within 5-12 working days.

DNA / RNA Damage Antibody

abx443691-100ug 100 ug
EUR 565
  • Shipped within 5-12 working days.

DNA / RNA Damage Antibody

abx443972-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

DNA / RNA Damage Antibody

abx444253-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

DNA / RNA Damage Antibody

abx444534-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

DNA / RNA Damage Antibody

20-abx444884
  • EUR 495.00
  • EUR 328.00
  • 100 ug
  • 25 ug
  • Shipped within 5-12 working days.

OxiSelect Oxidative DNA Damage Quantitation Kit (AP sites)

STA-324 50 assays
EUR 780
Description: DNA damage can manifest in the formation of apurinic or apyrimidinic (AP or abasic) sites. Such spontaneous base loss in mammalian cells has been estimated at between 50,000 and 200,000 sites per day. Unrepaired abasic sites can inhibit transcription and may be mutagenic. Our OxiSelect Oxidative DNA Damage Quantitation Kit provides a simple, user-friendly method for the quantitaiton DNA damage in the form of abasic sites. The assay uses an Aldehyde Reactive Probe (ARP) to specifically react with an aldehyde group on the open ring of the AP site. This allows the AP site to be labeled with Biotin, followed by detection with Streptavidin-Enzyme conjugate.

Monoclonal antibody for DNA/RNA Damage

SMC-155C 0.025mg
EUR 190
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

Monoclonal antibody for DNA/RNA Damage

SMC-155D 0.1mg
EUR 332
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A390 0.1mg
EUR 379
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 390.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A488 0.1mg
EUR 378
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 488.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A565 0.1mg
EUR 378
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 565.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A594 0.1mg
EUR 378
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 594.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A633 0.1mg
EUR 378
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 633.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A655 0.1mg
EUR 378
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 655.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A680 0.1mg
EUR 378
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 680.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-A700 0.1mg
EUR 378
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 700.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-ALP 0.1mg
EUR 372
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Alkaline Phosphatase.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-APC 0.1mg
EUR 377
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-APCCY7 0.1mg
EUR 450
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC/Cy7.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-BI 0.1mg
EUR 374
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Biotin.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY350 0.1mg
EUR 393
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 350.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY405 0.1mg
EUR 381
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 405.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY488 0.1mg
EUR 371
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 488.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY594 0.1mg
EUR 373
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 594.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-DY633 0.1mg
EUR 368
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 633.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-FITC 0.1mg
EUR 370
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with FITC.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-HRP 0.1mg
EUR 366
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with HRP.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-P594 0.1mg
EUR 385
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PE/ATTO 594.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-PCP 0.1mg
EUR 377
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PerCP.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-RPE 0.1mg
EUR 375
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with RPE.

Monoclonal antibody for DNA/RNA Damage

SMC-155D-STR 0.1mg
EUR 376
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Streptavidin.

Monoclonal antibody for DNA/RNA Damage

SMC-155S 0.012mg
EUR 65
  • DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are
  • Show more
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated.

OxiSelect Oxidative DNA Damage Quantitation Kit (AP Sites), Trial Size

STA-324-T 10 assays
EUR 415
Description: DNA damage can manifest in the formation of apurinic or apyrimidinic (AP or abasic) sites. Such spontaneous base loss in mammalian cells has been estimated at between 50,000 and 200,000 sites per day. Unrepaired abasic sites can inhibit transcription and may be mutagenic. Our OxiSelect Oxidative DNA Damage Quantitation Kit provides a simple, user-friendly method for the quantitaiton DNA damage in the form of abasic sites. The assay uses an Aldehyde Reactive Probe (ARP) to specifically react with an aldehyde group on the open ring of the AP site. This allows the AP site to be labeled with Biotin, followed by detection with Streptavidin-Enzyme conjugate.

OxiSelect Oxidative RNA Damage ELISA Kit (8-OHG Quantitation) (96 tests)

STA-325 96 assays
EUR 960
Description: Recently oxidative RNA damage has been described in conjunction with a wide variety of neurological diseases including Alzheimer?s disease, Parkinson?s disease, Dementia with Lewy Bodies, prion disease, and subacute sclerosing panencephalitis. We have developed an easy-to-use ELISA for the detection of the most common marker of RNA damage: 8-hydroxyguanosine (8-OHG).

OxiSelect Oxidative RNA Damage ELISA Kit (8-OHG Quantitation) (5x96 tests)

STA-325-5 5 x 96 assays
EUR 3953
Description: Recently oxidative RNA damage has been described in conjunction with a wide variety of neurological diseases including Alzheimer?s disease, Parkinson?s disease, Dementia with Lewy Bodies, prion disease, and subacute sclerosing panencephalitis. We have developed an easy-to-use ELISA for the detection of the most common marker of RNA damage: 8-hydroxyguanosine (8-OHG).

OxiSelect Oxidative RNA Damage ELISA Kit (8-OHG Quantitation), Trial Size

STA-325-T 32 assays
EUR 508
Description: Recently oxidative RNA damage has been described in conjunction with a wide variety of neurological diseases including Alzheimer?s disease, Parkinson?s disease, Dementia with Lewy Bodies, prion disease, and subacute sclerosing panencephalitis. We have developed an easy-to-use ELISA for the detection of the most common marker of RNA damage: 8-hydroxyguanosine (8-OHG).

OxiSelect Oxidative DNA Damage ELISA Kit (8-OHdG Quantitation) (1 plate)

STA-320 96 assays
EUR 960
Description: Among numerous types of oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG) is a ubiquitous marker of oxidative stress. 8-OHdG, one of the byproducts of oxidative DNA damage, is physiologically formed and enhanced by chemical carcinogens. Our OxiSelect Oxidative DNA Damage ELISA Kit (8-hydroxydeoxyguanosine assay) provides a powerful method for rapid, sensitive quantitation of 8-OHdG in DNA samples.

OxiSelect Oxidative DNA Damage ELISA Kit (8-OHdG Quantitation) (5 plates)

STA-320-5 5 x 96 assays
EUR 3953
Description: Among numerous types of oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG) is a ubiquitous marker of oxidative stress. 8-OHdG, one of the byproducts of oxidative DNA damage, is physiologically formed and enhanced by chemical carcinogens. Our OxiSelect Oxidative DNA Damage ELISA Kit (8-hydroxydeoxyguanosine assay) provides a powerful method for rapid, sensitive quantitation of 8-OHdG in DNA samples.

OxiSelect Oxidative DNA Damage ELISA Kit (8-OHdG Quantitation), Trial Size

STA-320-T 32 assays
EUR 508
Description: Among numerous types of oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG) is a ubiquitous marker of oxidative stress. 8-OHdG, one of the byproducts of oxidative DNA damage, is physiologically formed and enhanced by chemical carcinogens. Our OxiSelect Oxidative DNA Damage ELISA Kit (8-hydroxydeoxyguanosine assay) provides a powerful method for rapid, sensitive quantitation of 8-OHdG in DNA samples.

DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody

20-abx005629
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody

abx148136-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody

20-abx320325
  • EUR 300.00
  • EUR 244.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody

20-abx321453
  • EUR 300.00
  • EUR 244.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

DiscoveryProbe? DNA Damage/DNA Repair Library

L1033-.1 100 uL/well(10 mM solution)
EUR 3889

DiscoveryProbe? DNA Damage/DNA Repair Library

L1033-.25 250 uL/well(10 mM solution)
EUR 6905

DiscoveryProbe? DNA Damage/DNA Repair Library

L1033-5 5 mg/well
EUR 9005

DNA Damage Quantification Kit

55R-1345 25 assays
EUR 844
Description: Assay Kit for Quantification of DNA Damage in the research laboratory

OxiSelect Nitrosative DNA/RNA Damage ELISA Kit (8-Nitroguanine Quantitation)

STA-825 96 assays
EUR 798
Description: The OxiSelect Nitrosative DNA/RNA Damage ELISA Kit is a competitive enzyme immunoassay developed for rapid detection and quantitation of 8-nitroguanine in urine, serum, or plasma samples.

OxiSelect Nitrosative DNA/RNA Damage ELISA Kit (8-Nitroguanine Quantitation)

STA-825-5 5 x 96 assays
EUR 3240
Description: The OxiSelect Nitrosative DNA/RNA Damage ELISA Kit is a competitive enzyme immunoassay developed for rapid detection and quantitation of 8-nitroguanine in urine, serum, or plasma samples.

Green RNA Lysis Kit 50

GREENE1-RNA 50pack
EUR 180
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Green RNA Lysis Kit 250

GREENE5-RNA 250pack
EUR 571
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Navy RNA Lysis Kit 50

NAVYE1-RNA 50pack
EUR 198
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Navy RNA Lysis Kit 250

NAVYE5-RNA 250pack
EUR 651
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Pink RNA Lysis Kit 50

PINKE1-RNA 50pack
EUR 178
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Pink RNA Lysis Kit 250

PINKE5-RNA 250pack
EUR 561
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RNA Lysis Kit 50

REDE1-RNA 50pack
EUR 192
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RNA Lysis Kit 250

REDE5-RNA 250pack
EUR 622
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RNA Lysis Kit 50

YELLOWE1-RNA 50pack
EUR 192
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RNA Lysis Kit 250

YELLOWE5-RNA 250pack
EUR 624
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

5E GREEN RNA Lysis Kit 100

GREEN5E100-RNA 100pack
EUR 386
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 1000, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

5E GREEN RNA Lysis Kit 20

GREEN5E20-RNA 20pack
EUR 138
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Green RINO RNA Lysis Kit 50

GREENR1-RNA 50pack
EUR 184
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free.

Green RINO RNA Lysis Kit 250

GREENR5-RNA 250pack
EUR 587
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free.

5E Navy RNA Lysis Kit 100

NAVY5E100-RNA 100pack
EUR 453
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

5E Navy RNA Lysis Kit 20

NAVY5E20-RNA 20pack
EUR 153
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Navy RINO RNA Lysis Kit 50

NAVYR1-RNA 50pack
EUR 202
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free.

Navy RINO RNA Lysis Kit 250

NAVYR5-RNA 250pack
EUR 666
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free.

5E PINK RNA Lysis Kit 100

PINK5E100-RNA 100pack
EUR 380
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

5E PINK RNA Lysis Kit 20

PINK5E20-RNA 20pack
EUR 136
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Pink RINO RNA Lysis Kit 50

PINKR1-RNA 50pack
EUR 181
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Pink RINO RNA Lysis Kit 250

PINKR5-RNA 250pack
EUR 576
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

5E RED RNA Lysis Kit 100

RED5E100-RNA 100pack
EUR 429
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

5E RED RNA Lysis Kit 20

RED5E20-RNA 20pack
EUR 148
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RINO RNA Lysis Kit 50

REDR1-RNA 50pack
EUR 195
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Red RINO RNA Lysis Kit 250

REDR5-RNA 250pack
EUR 638
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RINO RNA Lysis Kit 50

YELLOWR1-RNA 50pack
EUR 199
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RINO RNA Lysis Kit 250

YELLOWR5-RNA 250pack
EUR 656
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

DNA Damage Quantification Colorimetric Kit

K253-25
EUR 610

DNA Damage Quantification Colorimetric Kit

K2100-25 25 assays
EUR 627

VAHTS DNA Damage Repair Kit

N208-01 24 rxn
EUR 263

VAHTS DNA Damage Repair Kit

N208-02 96 rxn
EUR 642

100 BP DNA LADDER, 500UL PER KIT

M-DNA-100BP 1/pk
EUR 73
Description: Bioscience Mol Bio; DNA Ladder

1 KB DNA LADDER, 500UL PER KIT

M-DNA-1KB 1/pk
EUR 70
Description: Bioscience Mol Bio; DNA Ladder

DNA Damage Inducible Transcript 3 (DDIT3) Antibody

abx026524-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

DNA Damage Inducible Transcript 3 (DDIT3) Antibody

abx026524-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

DNA Damage Inducible Transcript 3 (DDIT3) Antibody

20-abx004988
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

DNA Damage Inducible Transcript 3 (DDIT3) Antibody

abx027183-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

A genome-wide display screen for differentially methylated lengthy noncoding RNAs recognized that lncAC007255.Eight is regulated by promoter DNA methylation in Beas-2B cells malignantly reworked by NNK

 Tobacco publicity is well-known to induce genetic and epigenetic adjustments that contribute to the pathogenesis of lung most cancers. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a big tobacco-specific carcinogen, however the oncogenic mechanisms of NNK haven’t been completely elucidated. On this examine we discovered that DNA methyltransferase 1(DNMT1) was overexpressed in malignantly reworked human bronchial epithelial Beas-2B cells induced by NNK (2B-NNK cells), by therapy with NNK (400 μg/ml) for 7 days. An Arraystar Human noncoding RNA Promoter Microarray was used to detect the DNA methylation standing of the promoter area of lengthy noncoding RNAs (lncRNAs). The outcome confirmed that 1010 differentially methylated fragments had been current within the lncRNA promoter area. QRT-PCR revealed that the expression of lncRNA AC007255.Eight was remarkably downregulated in 2B-NNK cells and lung most cancers tissues.

Moreover, Methylation-particular PCR confirmed that the methylation of the lncRNA AC007255.Eight promoter was elevated in 2B-NNK cells and lung most cancers tissues. The lowered expression of lncRNA AC007255.Eight was considerably related to hypermethylation of lncRNA AC007255.Eight promoter area. LncRNA AC007255.Eight overexpression may lead to decreased cell proliferation and elevated cell apoptosis in 2B-NNK cells. In conclusion, NNK induced lncRNA AC007255.8 promoter hypermethylation by way of upregulation of DNMT1 in Beas-2B cells, resulting in downregulation of lncRNA AC007255.8, and finally the enhancement of cell proliferation and the inhibition of apoptosis. This analysis affords novel insights into the epigenetic mechanisms of lung most cancers, and can stimulate additional analysis into the involvement of aberrant DNA methylation of non-coding areas of the genome within the pathogenesis of lung most cancers.

Detecting protein and DNA/RNA constructions in cryo-EM maps of intermediate decision utilizing deep studying

 

An growing variety of density maps of macromolecular constructions, together with proteins and DNA/RNA complexes, have been decided by cryo-electron microscopy (cryo-EM). Though these days maps at a near-atomic decision are routinely reported, there are nonetheless substantial fractions of maps decided at intermediate or low resolutions, the place extracting construction data shouldn’t be trivial. Right here, we report a brand new computational methodology, Emap2sec+, which identifies DNA or RNA as properly because the secondary constructions of proteins in cryo-EM maps of 5 to 10 Å decision.

Emap2sec+ employs the deep Residual convolutional neural community. Emap2sec+ assigns structural labels with related possibilities at every voxel in a cryo-EM map, which can assist construction modeling in an EM map. Emap2sec+ confirmed secure and excessive task accuracy for nucleotides in low decision maps and improved efficiency for protein secondary construction assignments than its earlier model when examined on simulated and experimental maps.

 

Temporal panorama of human intestine RNA and DNA virome in SARS-CoV-2 an infection and severity

 

Background: Coronavirus illness 2019 (COVID-19) brought on by the enveloped RNA virus SARS-CoV-2 primarily impacts the respiratory and gastrointestinal tracts. SARS-CoV-2 was remoted from fecal samples, and energetic viral replication was reported in human intestinal cells. The human intestine additionally harbors an unlimited quantity of resident viruses (collectively referred to as the virome) that play a task in regulating host immunity and illness pathophysiology. Understanding intestine virome perturbation that underlies SARS-CoV-2 an infection and severity is an unmet want.

 

Strategies: We enrolled 98 COVID-19 sufferers with various illness severity (Three asymptomatic, 53 gentle, 34 reasonable, 5 extreme, Three important) and 78 non-COVID-19 controls matched for gender and co-morbidities. All topics had fecal specimens sampled at inclusion. Blood specimens had been collected for COVID-19 sufferers at admission to check for inflammatory markers and white cell counts. Amongst COVID-19 circumstances, 37 (38%) sufferers had serial fecal samples collected 2 to three occasions per week from time of hospitalization till after discharge. Utilizing shotgun metagenomics sequencing, we sequenced and profiled the fecal RNA and DNA virome. We investigated alterations and longitudinal dynamics of the intestine virome in affiliation with illness severity and blood parameters.

Outcomes: Sufferers with COVID-19 confirmed underrepresentation of Pepper gentle mottle virus (RNA virus) and a number of bacteriophage lineages (DNA viruses) and enrichment of environment-derived eukaryotic DNA viruses in fecal samples, in comparison with non-COVID-19 topics. Such intestine virome alterations continued as much as 30 days after illness decision. Fecal virome in SARS-CoV-2 an infection harbored extra stress-, inflammation-, and virulence-associated gene encoding capacities together with these pertaining to bacteriophage integration, DNA restore, and metabolism and virulence related to their bacterial host. Baseline fecal abundance of 10 virus species (1 RNA virus, pepper chlorotic spot virus, and 9 DNA virus species) inversely correlated with illness COVID-19 severity. These viruses inversely correlated with blood ranges of pro-inflammatory proteins, white cells, and neutrophils. Among the many 10 COVID-19 severity-associated DNA virus species, Four confirmed inverse correlation with age; 5 confirmed persistent decrease abundance each throughout illness course and after illness decision relative to non-COVID-19 topics.

Conclusions: Each enteric RNA and DNA virome in COVID-19 sufferers had been completely different from non-COVID-19 topics, which continued after illness decision of COVID-19. Intestine virome might calibrate host immunity and regulate severity to SARS-CoV-2 an infection. Our statement that intestine viruses inversely correlated with each severity of COVID-19 and host age might partly clarify that older topics are susceptible to extreme and worse COVID-19 outcomes. Altogether, our information spotlight the significance of human intestine virome in severity and probably therapeutics of COVID-19. Video Summary.