Systematic comparability and prediction of the consequences of missense mutations on protein-DNA and protein-RNA interactions
The binding affinities of protein-nucleic acid interactions may very well be altered as a consequence of missense mutations occurring in DNA- or RNA-binding proteins, subsequently leading to numerous illnesses. Sadly, a scientific comparability and prediction of the consequences of mutations on protein-DNA and protein-RNA interactions (these two mutation lessons are termed MPDs and MPRs, respectively) remains to be missing. Right here, we demonstrated that these two lessons of mutations may generate comparable or completely different tendencies for binding free power adjustments when it comes to the properties of mutated residues. We then developed regression algorithms individually for MPDs and MPRs by introducing novel geometric partition-based power options and interface-based structural options.
By characteristic choice and ensemble studying, comparable computational frameworks that built-in energy- and nonenergy-based fashions had been established to estimate the binding affinity adjustments ensuing from MPDs and MPRs, however the chosen options for the remaining fashions had been completely different and subsequently mirrored the specificity of those two mutation lessons. Moreover, the proposed methodology was prolonged to the identification of mutations that considerably decreased the binding affinities. In depth validations indicated that our algorithm typically carried out higher than the state-of-the-art strategies on each the regression and classification duties. The webserver and software program are freely obtainable at PEMPNI
Optimising glyphosate tolerance in rapeseed (Brassica napus L.) by CRISPR/Cas9-based geminiviral donor DNA replicon system with Csy4-based single-guide RNA processing
Rapeseed (Brassica napus L.) is a crucial oil crop worldwide, and efficient weed management can defend its yields and high quality. Farmers can profit from tolerant cultivars when utilizing herbicides, equivalent to glyphosate. Amino acid substitutions in enolpyruvylshikimate-3-phosphate synthase (EPSPS) render the plant much less delicate to glyphosate. Due to this fact, we aimed to optimise the glyphosate tolerance trait in rapeseed by way of endogenous EPSPS modification. To attain efficient gene substitute in B. napus L., we employed a CRISPR/Cas9 system expressing single-guide RNAs (sgRNAs) cleaved by the CRISPR-associated RNA endoribonuclease Csy4 from Pseudomonas aeruginosa for focused induction of double-strand breaks. Each the donor template and a geminiviral replicon harbouring an sgRNA expression cassette had been launched into plant cells.
Utilizing sgRNAs focusing on adjoining donor DNA template containing synonymous mutations in sgRNA websites, we achieved exact gene replacements within the endogenous B. napus EPSPS gene, BnaC04EPSPS, leading to TIPS and LFGAAGMCRL amino acid substitutions at frequencies as much as 20%. Rapeseed seedlings harbouring EPSPSmTIPS or EPSPSmLFGAAGMCRL had been glyphosate tolerant. Moreover, modifications in BnaC04EPSPS had been exactly transmitted to the following era. Our genome enhancing technique allows extremely environment friendly gene focusing on and the induction of glyphosate tolerance in oilseed rape.

bio-tech-inc
DNA / RNA Damage Antibody |
abx440040-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
DNA / RNA Damage Antibody |
abx440321-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
DNA / RNA Damage Antibody |
abx440602-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
DNA / RNA Damage Antibody |
abx440883-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
DNA / RNA Damage Antibody |
abx441164-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
DNA / RNA Damage Antibody |
abx441445-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
DNA / RNA Damage Antibody |
abx441726-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
DNA / RNA Damage Antibody |
abx442007-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
DNA / RNA Damage Antibody |
abx444253-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
DNA / RNA Damage Antibody |
abx444534-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
DNA / RNA Damage Antibody |
20-abx444884 |
Abbexa |
|
|
|
DNA / RNA Damage Antibody |
abx442288-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
DNA / RNA Damage Antibody |
abx442569-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
DNA / RNA Damage Antibody |
abx442850-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
DNA / RNA Damage Antibody |
abx443130-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
DNA / RNA Damage Antibody |
abx443410-100ug |
Abbexa |
100 ug |
EUR 644.4 |
|
DNA / RNA Damage Antibody |
abx443691-100ug |
Abbexa |
100 ug |
EUR 678 |
|
DNA / RNA Damage Antibody |
abx443972-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody |
20-abx320325 |
Abbexa |
|
|
|
DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody |
20-abx321453 |
Abbexa |
|
|
|
DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody |
20-abx005629 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody |
abx148136-100ug |
Abbexa |
100 ug |
EUR 526.8 |
|
Monoclonal antibody for DNA/RNA Damage |
SMC-155C |
Stressmarq |
0.025mg |
EUR 228 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D |
Stressmarq |
0.1mg |
EUR 398.4 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-A390 |
Stressmarq |
0.1mg |
EUR 454.8 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Dog | Rabbit DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 390. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-A488 |
Stressmarq |
0.1mg |
EUR 453.6 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 488. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-A565 |
Stressmarq |
0.1mg |
EUR 453.6 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 565. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-A594 |
Stressmarq |
0.1mg |
EUR 453.6 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 594. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-A633 |
Stressmarq |
0.1mg |
EUR 453.6 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 633. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-A655 |
Stressmarq |
0.1mg |
EUR 453.6 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 655. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-A680 |
Stressmarq |
0.1mg |
EUR 453.6 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 680. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-A700 |
Stressmarq |
0.1mg |
EUR 453.6 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with ATTO 700. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-ALP |
Stressmarq |
0.1mg |
EUR 446.4 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Alkaline Phosphatase. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-APC |
Stressmarq |
0.1mg |
EUR 452.4 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-APCCY7 |
Stressmarq |
0.1mg |
EUR 540 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with APC/Cy7. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-BI |
Stressmarq |
0.1mg |
EUR 448.8 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Biotin. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-DY350 |
Stressmarq |
0.1mg |
EUR 471.6 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 350. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-DY405 |
Stressmarq |
0.1mg |
EUR 457.2 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 405. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-DY488 |
Stressmarq |
0.1mg |
EUR 445.2 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 488. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-DY594 |
Stressmarq |
0.1mg |
EUR 447.6 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 594. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-DY633 |
Stressmarq |
0.1mg |
EUR 441.6 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Dylight 633. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-FITC |
Stressmarq |
0.1mg |
EUR 444 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with FITC. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-HRP |
Stressmarq |
0.1mg |
EUR 439.2 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with HRP. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-P594 |
Stressmarq |
0.1mg |
EUR 462 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PE/ATTO 594. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-PCP |
Stressmarq |
0.1mg |
EUR 452.4 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with PerCP. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-RPE |
Stressmarq |
0.1mg |
EUR 450 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with RPE. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155D-STR |
Stressmarq |
0.1mg |
EUR 451.2 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is conjugated with Streptavidin. |
Monoclonal antibody for DNA/RNA Damage |
SMC-155S |
Stressmarq |
0.012mg |
EUR 78 |
|
Description: A monoclonal antibody from clone 15A3 against Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus) DNA/RNA Damage. The host species for the production of this antibody is Mouse. The antigen used for immunization is 8-hydroxy-guanosine-BSA and ?casein conjugates. The antibody is tested and validated for IHC, ICC/IF, ELISA, DB, IP, FCM, FA assays with the following recommended dilutions: IHC (1:1000). This MAb for DNA/RNA Damage is not conjugated. |
Oxidative-Stress Responsive 1 (OXSR1) Antibody |
20-abx114290 |
Abbexa |
|
|
|
Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody |
abx236027-100ug |
Abbexa |
100 ug |
EUR 610.8 |
|
Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody |
20-abx114289 |
Abbexa |
|
|
|
Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody |
abx146030-100ug |
Abbexa |
100 ug |
EUR 469.2 |
|
Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody |
20-abx173928 |
Abbexa |
|
|
|
Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody |
20-abx128290 |
Abbexa |
-
EUR 510.00
-
EUR 159.60
-
EUR 1446.00
-
EUR 693.60
-
EUR 393.60
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody |
abx029975-400ul |
Abbexa |
400 ul |
EUR 627.6 |
|
Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Antibody |
abx029975-80l |
Abbexa |
80 µl |
EUR 343.2 |
|
Human Oxidative Stress-Responsive 1 Protein (OXSR1) Antibody |
33219-05111 |
AssayPro |
150 ug |
EUR 313.2 |
Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody |
abx122927-100ug |
Abbexa |
100 ug |
EUR 469.2 |
|
Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody |
20-abx302885 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Recombinant Human DNA oxidative demethylase ALKBH2 Protein, GST, E.coli-10ug |
QP7771-ec-10ug |
EnQuireBio |
10ug |
EUR 240 |
Recombinant Human DNA oxidative demethylase ALKBH2 Protein, GST, E.coli-1mg |
QP7771-ec-1mg |
EnQuireBio |
1mg |
EUR 1958.4 |
Recombinant Human DNA oxidative demethylase ALKBH2 Protein, GST, E.coli-50ug |
QP7771-ec-50ug |
EnQuireBio |
50ug |
EUR 315.6 |
Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody (HRP) |
20-abx312498 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody (FITC) |
20-abx312499 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Recombinant Human DNA oxidative demethylase ALKBH2 Protein, GST, E.coli-100ug |
QP7771-ec-100ug |
EnQuireBio |
100ug |
EUR 489.6 |
Recombinant Human DNA oxidative demethylase ALKBH2 Protein, GST, E.coli-200ug |
QP7771-ec-200ug |
EnQuireBio |
200ug |
EUR 760.8 |
Recombinant Human DNA oxidative demethylase ALKBH2 Protein, GST, E.coli-500ug |
QP7771-ec-500ug |
EnQuireBio |
500ug |
EUR 1272 |
Oxidative Stress-Induced Growth Inhibitor 2 (OSGIN2) Antibody (Biotin) |
20-abx312500 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Oxidative Stress-Responsive Serine-Rich Protein 1 (OSER1) Antibody |
20-abx318659 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Human Oxidative Stress-Responsive 1 Protein (OXSR1) Antibody (Biotin Conjugate) |
33219-05121 |
AssayPro |
150 ug |
EUR 442.8 |
Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Polyclonal Antibody (Human) |
4-PAG202Hu01 |
Cloud-Clone |
-
EUR 296.40
-
EUR 3012.00
-
EUR 750.00
-
EUR 372.00
-
EUR 256.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) |
8-isoprostane oxidative stress ELISA Kit |
8iso1 |
Detroit R&D |
1 Kit |
EUR 368.4 |
Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Polyclonal Antibody (Human), APC |
4-PAG202Hu01-APC |
Cloud-Clone |
-
EUR 414.00
-
EUR 3930.00
-
EUR 1094.40
-
EUR 528.00
-
EUR 262.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1). This antibody is labeled with APC. |
Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Polyclonal Antibody (Human), Cy3 |
4-PAG202Hu01-Cy3 |
Cloud-Clone |
-
EUR 502.80
-
EUR 5190.00
-
EUR 1410.00
-
EUR 654.00
-
EUR 301.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1). This antibody is labeled with Cy3. |
Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Polyclonal Antibody (Human), HRP |
4-PAG202Hu01-HRP |
Cloud-Clone |
-
EUR 379.20
-
EUR 3426.00
-
EUR 968.40
-
EUR 477.60
-
EUR 247.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1). This antibody is labeled with HRP. |
Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Polyclonal Antibody (Human), PE |
4-PAG202Hu01-PE |
Cloud-Clone |
-
EUR 355.20
-
EUR 3168.00
-
EUR 900.00
-
EUR 446.40
-
EUR 234.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1). This antibody is labeled with PE. |
Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Polyclonal Antibody (Human), FITC |
4-PAG202Hu01-FITC |
Cloud-Clone |
-
EUR 355.20
-
EUR 3168.00
-
EUR 900.00
-
EUR 446.40
-
EUR 234.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1). This antibody is labeled with FITC. |
Human Oxidative Stress-Responsive 1 Protein (OXSR1) AssayLite Antibody (RPE Conjugate) |
33219-05151 |
AssayPro |
150 ug |
EUR 513.6 |
Human Oxidative Stress-Responsive 1 Protein (OXSR1) AssayLite Antibody (APC Conjugate) |
33219-05161 |
AssayPro |
150 ug |
EUR 513.6 |
Human Oxidative Stress-Responsive 1 Protein (OXSR1) AssayLite Antibody (FITC Conjugate) |
33219-05141 |
AssayPro |
150 ug |
EUR 513.6 |
Human Oxidative Stress-Responsive 1 Protein (OXSR1) AssayLite Antibody (PerCP Conjugate) |
33219-05171 |
AssayPro |
150 ug |
EUR 565.2 |
Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Polyclonal Antibody (Human), APC-Cy7 |
4-PAG202Hu01-APC-Cy7 |
Cloud-Clone |
-
EUR 685.20
-
EUR 7716.00
-
EUR 2046.00
-
EUR 912.00
-
EUR 382.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1). This antibody is labeled with APC-Cy7. |
Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1) Polyclonal Antibody (Human), Biotinylated |
4-PAG202Hu01-Biotin |
Cloud-Clone |
-
EUR 373.20
-
EUR 2952.00
-
EUR 872.40
-
EUR 457.20
-
EUR 262.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1). This antibody is labeled with Biotin. |
DNA Damage-Binding Protein 1 (DDB1) Antibody |
abx232284-100ug |
Abbexa |
100 ug |
EUR 577.2 |
|
DNA Damage-Binding Protein 1 (DDB1) Antibody |
20-abx333999 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
DNA Damage-Binding Protein 2 (DDB2) Antibody |
20-abx338922 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
OxiSelect Nitrosative DNA/RNA Damage ELISA Kit (8-Nitroguanine Quantitation) |
STA-825 |
Cell Biolabs |
96 assays |
EUR 957.6 |
Description: The OxiSelect Nitrosative DNA/RNA Damage ELISA Kit is a competitive enzyme immunoassay developed for rapid detection and quantitation of 8-nitroguanine in urine, serum, or plasma samples. |
OxiSelect Nitrosative DNA/RNA Damage ELISA Kit (8-Nitroguanine Quantitation) |
STA-825-5 |
Cell Biolabs |
5 x 96 assays |
EUR 3888 |
Description: The OxiSelect Nitrosative DNA/RNA Damage ELISA Kit is a competitive enzyme immunoassay developed for rapid detection and quantitation of 8-nitroguanine in urine, serum, or plasma samples. |
Human Oxidative Stress-Responsive 1 Protein (OXSR1) AssayLite Antibody (FITC, RPE, APC, PerCP Conjugate) |
33219-05181 |
AssayPro |
1 x 75 ug, 3 x 30 ug |
EUR 702 |
DNA Damage Inducible Transcript 4 (DDIT4) Antibody |
20-abx213754 |
Abbexa |
|
|
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
20-abx172142 |
Abbexa |
|
|
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
20-abx326210 |
Abbexa |
|
|
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
20-abx000607 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
20-abx004988 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
20-abx103576 |
Abbexa |
-
EUR 510.00
-
EUR 159.60
-
EUR 1446.00
-
EUR 693.60
-
EUR 393.60
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
20-abx112119 |
Abbexa |
|
|
|
DNA Damage Inducible Transcript 4 (DDIT4) Antibody |
20-abx112120 |
Abbexa |
|
|
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
20-abx176186 |
Abbexa |
|
|
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
20-abx125748 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
20-abx125750 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
DNA Damage Inducible Transcript 4 (DDIT4) Antibody |
20-abx241498 |
Abbexa |
|
|
|
DNA Damage Inducible Transcript 4 (DDIT4) Antibody |
20-abx123209 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
20-abx129884 |
Abbexa |
-
EUR 526.80
-
EUR 159.60
-
EUR 1479.60
-
EUR 710.40
-
EUR 393.60
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
20-abx301173 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
abx026524-400ul |
Abbexa |
400 ul |
EUR 627.6 |
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
abx026524-80l |
Abbexa |
80 µl |
EUR 343.2 |
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
abx027183-400ul |
Abbexa |
400 ul |
EUR 627.6 |
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
abx027183-80l |
Abbexa |
80 µl |
EUR 343.2 |
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
abx332226-100ul |
Abbexa |
100 ul |
EUR 510 |
|
DNA Damage Inducible Transcript 3 (DDIT3) Antibody |
20-abx329652 |
Abbexa |
|
|
|
P53 And Dna Damage Regulated 1 (PDRG1) Antibody |
20-abx114308 |
Abbexa |
|
|
|
P53 And DNA Damage Regulated 1 (PDRG1) Antibody |
20-abx328877 |
Abbexa |
|
|
|
P53 And DNA Damage Regulated 1 (PDRG1) Antibody |
20-abx014692 |
Abbexa |
-
EUR 376.80
-
EUR 117.60
-
EUR 477.60
-
EUR 594.00
|
- 100 ug
- 10 ug
- 200 ug
- 300 µg
|
|
P53 And DNA Damage Regulated 1 (PDRG1) Antibody |
20-abx008020 |
Abbexa |
-
EUR 360.00
-
EUR 526.80
-
EUR 226.80
|
|
|
P53 And DNA Damage Regulated 1 (PDRG1) Antibody |
abx236289-100ug |
Abbexa |
100 ug |
EUR 577.2 |
|
A genome-wide display screen for differentially methylated lengthy noncoding RNAs recognized that lncAC007255.Eight is regulated by promoter DNA methylation in Beas-2B cells malignantly reworked by NNK
Tobacco publicity is well-known to induce genetic and epigenetic adjustments that contribute to the pathogenesis of lung most cancers. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a big tobacco-specific carcinogen, however the oncogenic mechanisms of NNK haven’t been completely elucidated. On this examine we discovered that DNA methyltransferase 1(DNMT1) was overexpressed in malignantly reworked human bronchial epithelial Beas-2B cells induced by NNK (2B-NNK cells), by therapy with NNK (400 μg/ml) for 7 days. An Arraystar Human noncoding RNA Promoter Microarray was used to detect the DNA methylation standing of the promoter area of lengthy noncoding RNAs (lncRNAs). The outcome confirmed that 1010 differentially methylated fragments had been current within the lncRNA promoter area. QRT-PCR revealed that the expression of lncRNA AC007255.Eight was remarkably downregulated in 2B-NNK cells and lung most cancers tissues.
Moreover, Methylation-particular PCR confirmed that the methylation of the lncRNA AC007255.Eight promoter was elevated in 2B-NNK cells and lung most cancers tissues. The lowered expression of lncRNA AC007255.Eight was considerably related to hypermethylation of lncRNA AC007255.Eight promoter area. LncRNA AC007255.Eight overexpression may lead to decreased cell proliferation and elevated cell apoptosis in 2B-NNK cells. In conclusion, NNK induced lncRNA AC007255.8 promoter hypermethylation by way of upregulation of DNMT1 in Beas-2B cells, resulting in downregulation of lncRNA AC007255.8, and finally the enhancement of cell proliferation and the inhibition of apoptosis. This analysis affords novel insights into the epigenetic mechanisms of lung most cancers, and can stimulate additional analysis into the involvement of aberrant DNA methylation of non-coding areas of the genome within the pathogenesis of lung most cancers.
Detecting protein and DNA/RNA constructions in cryo-EM maps of intermediate decision utilizing deep studying
An growing variety of density maps of macromolecular constructions, together with proteins and DNA/RNA complexes, have been decided by cryo-electron microscopy (cryo-EM). Though these days maps at a near-atomic decision are routinely reported, there are nonetheless substantial fractions of maps decided at intermediate or low resolutions, the place extracting construction data shouldn’t be trivial. Right here, we report a brand new computational methodology, Emap2sec+, which identifies DNA or RNA as properly because the secondary constructions of proteins in cryo-EM maps of 5 to 10 Å decision.
Emap2sec+ employs the deep Residual convolutional neural community. Emap2sec+ assigns structural labels with related possibilities at every voxel in a cryo-EM map, which can assist construction modeling in an EM map. Emap2sec+ confirmed secure and excessive task accuracy for nucleotides in low decision maps and improved efficiency for protein secondary construction assignments than its earlier model when examined on simulated and experimental maps.
Temporal panorama of human intestine RNA and DNA virome in SARS-CoV-2 an infection and severity
Background: Coronavirus illness 2019 (COVID-19) brought on by the enveloped RNA virus SARS-CoV-2 primarily impacts the respiratory and gastrointestinal tracts. SARS-CoV-2 was remoted from fecal samples, and energetic viral replication was reported in human intestinal cells. The human intestine additionally harbors an unlimited quantity of resident viruses (collectively referred to as the virome) that play a task in regulating host immunity and illness pathophysiology. Understanding intestine virome perturbation that underlies SARS-CoV-2 an infection and severity is an unmet want.
Strategies: We enrolled 98 COVID-19 sufferers with various illness severity (Three asymptomatic, 53 gentle, 34 reasonable, 5 extreme, Three important) and 78 non-COVID-19 controls matched for gender and co-morbidities. All topics had fecal specimens sampled at inclusion. Blood specimens had been collected for COVID-19 sufferers at admission to check for inflammatory markers and white cell counts. Amongst COVID-19 circumstances, 37 (38%) sufferers had serial fecal samples collected 2 to three occasions per week from time of hospitalization till after discharge. Utilizing shotgun metagenomics sequencing, we sequenced and profiled the fecal RNA and DNA virome. We investigated alterations and longitudinal dynamics of the intestine virome in affiliation with illness severity and blood parameters.
Outcomes: Sufferers with COVID-19 confirmed underrepresentation of Pepper gentle mottle virus (RNA virus) and a number of bacteriophage lineages (DNA viruses) and enrichment of environment-derived eukaryotic DNA viruses in fecal samples, in comparison with non-COVID-19 topics. Such intestine virome alterations continued as much as 30 days after illness decision. Fecal virome in SARS-CoV-2 an infection harbored extra stress-, inflammation-, and virulence-associated gene encoding capacities together with these pertaining to bacteriophage integration, DNA restore, and metabolism and virulence related to their bacterial host. Baseline fecal abundance of 10 virus species (1 RNA virus, pepper chlorotic spot virus, and 9 DNA virus species) inversely correlated with illness COVID-19 severity. These viruses inversely correlated with blood ranges of pro-inflammatory proteins, white cells, and neutrophils. Among the many 10 COVID-19 severity-associated DNA virus species, Four confirmed inverse correlation with age; 5 confirmed persistent decrease abundance each throughout illness course and after illness decision relative to non-COVID-19 topics.
Conclusions: Each enteric RNA and DNA virome in COVID-19 sufferers had been completely different from non-COVID-19 topics, which continued after illness decision of COVID-19. Intestine virome might calibrate host immunity and regulate severity to SARS-CoV-2 an infection. Our statement that intestine viruses inversely correlated with each severity of COVID-19 and host age might partly clarify that older topics are susceptible to extreme and worse COVID-19 outcomes. Altogether, our information spotlight the significance of human intestine virome in severity and probably therapeutics of COVID-19. Video Summary.
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